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Ces1a carboxylesterase 1A [ Mus musculus (house mouse) ]

Gene ID: 244595, updated on 8-Feb-2024

Summary

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Official Symbol
Ces1aprovided by MGI
Official Full Name
carboxylesterase 1Aprovided by MGI
Primary source
MGI:MGI:3648919
See related
Ensembl:ENSMUSG00000071047 AllianceGenome:MGI:3648919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces1l; Gm4976; EG244595
Summary
Predicted to enable sterol esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in testis. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
8 C5; 8 44.99 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93746842..93774820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93020214..93048192, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2947 Neighboring gene solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Neighboring gene STARR-seq mESC enhancer starr_22328 Neighboring gene carboxylesterase 1B Neighboring gene STARR-seq mESC enhancer starr_22331 Neighboring gene carboxylesterase 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate. Jin Q, et al. Chem Biol Interact, 2022 Dec 1. PMID 36174736
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate.
    Title: Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC102259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carboxylesterase 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013764.2 → NP_001013786.2  carboxylesterase 1-like precursor

    Status: VALIDATED

    Source sequence(s)
    AC140217, BC089371
    Consensus CDS
    CCDS22526.1
    UniProtKB/TrEMBL
    E9PYP1, Q5FWH4
    Related
    ENSMUSP00000092836.5, ENSMUST00000095211.5
    Conserved Domains (1) summary
    cd00312
    Location:25 → 536
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93746842..93774820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243550.2 → XP_030099410.1  carboxylesterase 1-like isoform X2

    Conserved Domains (1) summary
    pfam00135
    Location:26 → 436
    COesterase; Carboxylesterase family

  2. XM_017312820.3 → XP_017168309.1  carboxylesterase 1-like isoform X1

    Conserved Domains (1) summary
    pfam00135
    Location:29 → 440
    COesterase; Carboxylesterase family

  3. XM_006530999.3 → XP_006531062.1  carboxylesterase 1-like isoform X3

    Conserved Domains (1) summary
    pfam00135
    Location:1 → 410
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version

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