Defb14 defensin beta 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defb14provided by MGI
Official Full Name: defensin beta 14provided by MGI
Primary source: MGI:MGI:2675345
See related: Ensembl:ENSMUSG00000046354 AllianceGenome:MGI:2675345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BD-14
Summary: Enables chemoattractant activity. Acts upstream of or within cell chemotaxis and defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to several human genes including DEFB103A (defensin beta 103A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 5.3) and testis adult (RPKM 2.8) See more
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Genomic context

Location:: 8 A1.3; 8 10.35 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (19213172..19245342)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (19160244..19195309)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

although murine beta-defensin 14 might affect local skin microbial communities, it may further affect other healing parameters. Indeed, exogenously administered murine beta-defensin 14 directly delayed mouse primary keratinocyte scratch wound closure in vitro.
Title: Microbial Host Interactions and Impaired Wound Healing in Mice and Humans: Defining a Role for BD14 and NOD2.
this work demonstrates that mouse beta-defensin-14 can promote the maturation of dendritic cells in which TLR-4 is possibly involved
Title: Mouse β-defensin-14 for inducing the maturation of dendritic cells.
This study indicated that the potential antibacterial role of increased MBD-14 in the osteomyelitis mouse model.
Title: The potential role of increasing the release of mouse β- defensin-14 in the treatment of osteomyelitis in mice: a primary study.
BD14 expression by tumor-infiltrating host cells results in chemoattraction of CCR6-positive B220-positive lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis and organized tumor tissue development.
Title: Mouse β-defensin 14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner.
Murine beta-defensin-14, like ultraviolet radiation (UVR), can shift surface marker expression of CD4+CD25- T cells toward a regulatory (Treg) phenotype but does not appear to play a major role in UVR-induced immunosuppression.
Title: Induction of regulatory T cells by a murine β-defensin.
beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants
Title: Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds
Title: Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3.
Title: Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: beta-defensin 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.