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Usp35 ubiquitin specific peptidase 35 [ Mus musculus (house mouse) ]

Gene ID: 244144, updated on 5-Mar-2024

Summary

Official Symbol
Usp35provided by MGI
Official Full Name
ubiquitin specific peptidase 35provided by MGI
Primary source
MGI:MGI:2685339
See related
Ensembl:ENSMUSG00000035713 AllianceGenome:MGI:2685339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm493; Gm1088
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP35 (ubiquitin specific peptidase 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 2.8), cerebellum adult (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

Location:
7 E1; 7 53.47 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (96958610..96981502, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97309403..97332308, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) Neighboring gene STARR-positive B cell enhancer mm9_chr7:104233795-104234096 Neighboring gene STARR-seq mESC enhancer starr_19586 Neighboring gene STARR-seq mESC enhancer starr_19587 Neighboring gene growth factor receptor bound protein 2-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_19588 Neighboring gene STARR-seq mESC enhancer starr_19589 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104446044-104446345 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104480601-104480902 Neighboring gene STARR-seq mESC enhancer starr_19591 Neighboring gene potassium channel tetramerisation domain containing 21 Neighboring gene STARR-positive B cell enhancer ABC_E9293 Neighboring gene ALG8 alpha-1,3-glucosyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 35
Names
ubiquitin specific protease 35
NP_001170883.1
XP_006507886.1
XP_006507889.1
XP_006507892.1
XP_011240097.1
XP_011240099.1
XP_011240100.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177412.2NP_001170883.1  ubiquitin carboxyl-terminal hydrolase 35

    See identical proteins and their annotated locations for NP_001170883.1

    Status: VALIDATED

    Source sequence(s)
    AC155933
    Consensus CDS
    CCDS59734.1
    UniProtKB/TrEMBL
    M0QWN7
    Related
    ENSMUSP00000137726.2, ENSMUST00000139582.9
    Conserved Domains (2) summary
    cl02553
    Location:442916
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:441915
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    96958610..96981502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507823.5XP_006507886.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    Conserved Domains (1) summary
    cl02553
    Location:505979
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_006507826.1XP_006507889.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:225699
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  3. XM_011241797.2XP_011240099.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X4

    See identical proteins and their annotated locations for XP_011240099.1

    Conserved Domains (1) summary
    cl02553
    Location:10484
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  4. XM_006507829.2XP_006507892.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X4

    See identical proteins and their annotated locations for XP_006507892.1

    Conserved Domains (1) summary
    cl02553
    Location:10484
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  5. XM_011241795.4XP_011240097.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    Conserved Domains (1) summary
    cl02553
    Location:505979
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  6. XM_011241798.4XP_011240100.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X5

RNA

  1. XR_001785559.3 RNA Sequence

  2. XR_003946477.2 RNA Sequence

  3. XR_001785560.3 RNA Sequence

  4. XR_003946478.2 RNA Sequence

  5. XR_004934104.1 RNA Sequence