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Zdhhc13 zinc finger, DHHC domain containing 13 [ Mus musculus (house mouse) ]

Gene ID: 243983, updated on 5-Mar-2024

Summary

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Official Symbol
Zdhhc13provided by MGI
Official Full Name
zinc finger, DHHC domain containing 13provided by MGI
Primary source
MGI:MGI:1919227
See related
Ensembl:ENSMUSG00000030471 AllianceGenome:MGI:1919227
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
skc4; kojak; HIP3RP; Hip14l; C530010M18; 2410004E01Rik
Summary
Enables magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Predicted to be involved in protein palmitoylation. Located in Golgi membrane and Golgi-associated vesicle membrane. Is expressed in several structures, including early conceptus; esophagus epithelium; genitourinary system; molar; and sensory organ. Used to study Huntington's disease. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 21.6), bladder adult (RPKM 15.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B4; 7 31.11 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48438751..48477188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48788998..48827440)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45086 Neighboring gene VISTA enhancer mm1586 Neighboring gene predicted gene, 32263 Neighboring gene STARR-positive B cell enhancer ABC_E1734 Neighboring gene STARR-seq mESC enhancer starr_18887 Neighboring gene cysteine and glycine-rich protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E3719 Neighboring gene STARR-positive B cell enhancer ABC_E8174 Neighboring gene E2F transcription factor 8 Neighboring gene predicted gene 2788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. Chen LY, et al. J Invest Dermatol, 2020 May. PMID 31669413
  2. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. Perez CJ, et al. J Invest Dermatol, 2015 Dec. PMID 26288350, Free PMC Article
  3. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. Liu KM, et al. J Invest Dermatol, 2015 Nov. PMID 26121212
  4. Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. Song IW, et al. PLoS One, 2014. PMID 24637783, Free PMC Article
  5. Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model. Kang R, et al. Front Synaptic Neurosci, 2019. PMID 30846936, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.
    Title: Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.
  2. Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enables the normal occurrence of the fission-fusion process.
    Title: Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.
  3. The loss of ZDDHC13 in skin, impairs the multiple barrier functions and leads to a dermatitis lesion in response to microbial encounters.
    Title: Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.
  4. Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness
    Title: Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.
  5. Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 recognize peptide sequence in several unrelated proteins.
    Title: Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.
  6. Zdhhc13 regulates Smad6 during BMP-dependent signaling and early lineage decisions in an in vitro cell model.
    Title: Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity.
  7. Loss of Hip14 and Hip14l leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.
    Title: Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.
  8. Zdhhc13 is a novel regulator of postnatal skeletal development and bone mass acquisition.
    Title: Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.
  9. Hip14l-deficient mice develop adult-onset, neuropathological deficits characteristic of Huntington disease.
    Title: Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
  10. A second gene trap allele of Zdhhc13 has the same phenotypes, suggesting that this is a loss of function allele.
    Title: Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi-associated vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC13
Names
DHHC-13
HIP14-related protein
huntingtin-interacting protein 14-related protein
probable palmitoyltransferase ZDHHC13
zinc finger DHHC domain-containing protein 13
NP_082307.1
XP_006540959.1
XP_030098440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028031.3 → NP_082307.1  palmitoyltransferase ZDHHC13

    See identical proteins and their annotated locations for NP_082307.1

    Status: PROVISIONAL

    Source sequence(s)
    AC124977
    Consensus CDS
    CCDS52259.1
    UniProtKB/Swiss-Prot
    Q3UK32, Q3UKV1, Q9CWU2
    Related
    ENSMUSP00000112498.2, ENSMUST00000118927.8
    Conserved Domains (5) summary
    cd00204
    Location:79 → 192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:423 → 556
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:86 → 179
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:202 → 257
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:81 → 112
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    48438751..48477188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242580.2 → XP_030098440.1  palmitoyltransferase ZDHHC13 isoform X1

    UniProtKB/TrEMBL
    D3YY07
    Conserved Domains (4) summary
    COG0666
    Location:15 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:18 → 49
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:293 → 427
    DHHC; DHHC palmitoyltransferase
    cl26595
    Location:151 → 262
    DUF2070; Predicted membrane protein (DUF2070)

  2. XM_006540896.5 → XP_006540959.1  palmitoyltransferase ZDHHC13 isoform X1

    See identical proteins and their annotated locations for XP_006540959.1

    UniProtKB/TrEMBL
    D3YY07
    Related
    ENSMUSP00000123603.2, ENSMUST00000125280.8
    Conserved Domains (4) summary
    COG0666
    Location:15 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:18 → 49
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:293 → 427
    DHHC; DHHC palmitoyltransferase
    cl26595
    Location:151 → 262
    DUF2070; Predicted membrane protein (DUF2070)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWU2.2 GenPept UniProtKB/Swiss-Prot:Q9CWU2

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