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Ntn5 netrin 5 [ Mus musculus (house mouse) ]

Gene ID: 243967, updated on 8-May-2024

Summary

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Official Symbol
Ntn5provided by MGI
Official Full Name
netrin 5provided by MGI
Primary source
MGI:MGI:2685330
See related
Ensembl:ENSMUSG00000070564 AllianceGenome:MGI:2685330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm484
Summary
Predicted to enable signaling receptor binding activity. Involved in neurogenesis. Predicted to be located in extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including olfactory system; spinal component of peripheral nervous system; tail; trigeminal nerve; and vibrissa. Orthologous to human NTN5 (netrin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.9), cortex adult (RPKM 4.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45333519..45343980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45684022..45694556)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene sphingosine kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice. Ikegaya S, et al. Front Neurosci, 2020. PMID 33324143, Free PMC Article
  2. Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Garrett AM, et al. Front Mol Neurosci, 2016. PMID 26858598, Free PMC Article
  3. An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. Visser JJ, et al. Elife, 2015 Dec 2. PMID 26633812, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
netrin-5
Names
netrin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033356.4 → NP_001028528.2  netrin-5 isoform a precursor

    See identical proteins and their annotated locations for NP_001028528.2

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS39957.1
    UniProtKB/Swiss-Prot
    B9EKG6, Q3UQ22
    Related
    ENSMUSP00000103371.2, ENSMUST00000107742.11
    Conserved Domains (3) summary
    cd00055
    Location:227 → 276
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:313 → 438
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    cl02806
    Location:78 → 123
    Laminin_N; Laminin N-terminal (Domain VI)

  2. NM_001289692.2 → NP_001276621.1  netrin-5 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS80723.1
    UniProtKB/TrEMBL
    S4R1A5
    Related
    ENSMUSP00000138144.2, ENSMUST00000183120.4
    Conserved Domains (2) summary
    cd00055
    Location:227 → 276
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cl02806
    Location:78 → 123
    Laminin_N; Laminin N-terminal (Domain VI)

  3. NM_001289693.2 → NP_001276622.1  netrin-5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS71964.1
    UniProtKB/TrEMBL
    S4R1X6
    Related
    ENSMUSP00000138412.2, ENSMUST00000182750.10
    Conserved Domains (2) summary
    cd00055
    Location:158 → 207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:244 → 369
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  4. NM_001358870.2 → NP_001345799.1  netrin-5 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC167242
    UniProtKB/TrEMBL
    A0A140H8W8
    Conserved Domains (2) summary
    cd00055
    Location:290 → 339
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:376 → 501
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45333519..45343980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540888.5 → XP_006540951.1  netrin-5 isoform X3

    Conserved Domains (2) summary
    cd00055
    Location:290 → 339
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:366 → 482
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  2. XM_006540890.5 → XP_006540953.1  netrin-5 isoform X5

    Conserved Domains (2) summary
    cd00055
    Location:227 → 276
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:321 → 446
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  3. XM_006540885.5 → XP_006540948.1  netrin-5 isoform X1

    Conserved Domains (2) summary
    cd00055
    Location:290 → 339
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:384 → 509
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  4. XM_036153115.1 → XP_036009008.1  netrin-5 isoform X6

    Conserved Domains (2) summary
    cd00055
    Location:227 → 276
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:295 → 411
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  5. XM_006540889.5 → XP_006540952.1  netrin-5 isoform X4

    Conserved Domains (2) summary
    cd00055
    Location:290 → 339
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:358 → 474
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  6. XM_036153116.1 → XP_036009009.1  netrin-5 isoform X7

    Conserved Domains (2) summary
    cd00055
    Location:158 → 207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:252 → 377
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  7. XM_006540886.4 → XP_006540949.1  netrin-5 isoform X2

    Conserved Domains (2) summary
    cd00055
    Location:285 → 334
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:379 → 504
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  8. XM_006540893.5 → XP_006540956.1  netrin-5 isoform X9

    Conserved Domains (2) summary
    cd00055
    Location:153 → 202
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:247 → 372
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

  9. XM_006540892.4 → XP_006540955.1  netrin-5 isoform X8

    Conserved Domains (2) summary
    cd00055
    Location:158 → 207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:252 → 377
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

RNA

  1. XR_391341.5 RNA Sequence

  2. XR_391342.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UQ22.2 GenPept UniProtKB/Swiss-Prot:Q3UQ22

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