U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp473 zinc finger protein 473 [ Mus musculus (house mouse) ]

Gene ID: 243963, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp473provided by MGI
Official Full Name
zinc finger protein 473provided by MGI
Primary source
MGI:MGI:2442697
See related
Ensembl:ENSMUSG00000048012 AllianceGenome:MGI:2442697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf473; zfp-100; D030014N22Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and regulation of transcription by RNA polymerase II. Predicted to be located in Cajal body. Predicted to be active in nucleus. Is expressed in early conceptus; genitourinary system; and pancreas epithelium. Orthologous to human ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 2.1), testis adult (RPKM 0.6) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 B3; 7 28.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44380904..44398041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44731480..44748617, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 14 Neighboring gene RIKEN cDNA 2310016G11 gene Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene vaccinia related kinase 3 Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene predicted gene, 29791

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • 4932441F21

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 473 homolog
Names
zinc finger protein 100

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289836.1 → NP_001276765.1  zinc finger protein 473 homolog isoform 1

    See identical proteins and their annotated locations for NP_001276765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK030093, AK050747, BE446988, CD539573
    Consensus CDS
    CCDS21213.1
    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289837.1 → NP_001276766.1  zinc finger protein 473 homolog isoform 1

    See identical proteins and their annotated locations for NP_001276766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK050747, BE446988, CD539573
    Consensus CDS
    CCDS21213.1
    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Related
    ENSMUSP00000113774.2, ENSMUST00000120074.8
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289838.1 → NP_001276767.1  zinc finger protein 473 homolog isoform 2

    See identical proteins and their annotated locations for NP_001276767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK036453, AK050747, BE446988, CD539573
    Consensus CDS
    CCDS71952.1
    UniProtKB/TrEMBL
    Q4VA40
    Related
    ENSMUSP00000113316.2, ENSMUST00000118162.8
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:484 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:754 → 774
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001289839.1 → NP_001276768.1  zinc finger protein 473 homolog isoform 2

    See identical proteins and their annotated locations for NP_001276768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK036453, BC096555, BE446988
    Consensus CDS
    CCDS71952.1
    UniProtKB/TrEMBL
    Q4VA40
    Related
    ENSMUSP00000113789.2, ENSMUST00000120798.8
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:484 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:754 → 774
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  5. NM_178734.4 → NP_848849.2  zinc finger protein 473 homolog isoform 1

    See identical proteins and their annotated locations for NP_848849.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC150895, AK030093, AK050747, BE446988
    Consensus CDS
    CCDS21213.1
    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Related
    ENSMUSP00000051069.7, ENSMUST00000060270.13
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44380904..44398041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540879.1 → XP_006540942.1  zinc finger protein 473 homolog isoform X1

    See identical proteins and their annotated locations for XP_006540942.1

    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006540882.1 → XP_006540945.1  zinc finger protein 473 homolog isoform X2

    See identical proteins and their annotated locations for XP_006540945.1

    UniProtKB/TrEMBL
    Q4VA40
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:484 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:754 → 774
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011250862.1 → XP_011249164.1  zinc finger protein 473 homolog isoform X3

    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:484 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:754 → 774
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036153114.1 → XP_036009007.1  zinc finger protein 473 homolog isoform X2

    UniProtKB/TrEMBL
    Q4VA40
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:484 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:754 → 774
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006540881.4 → XP_006540944.1  zinc finger protein 473 homolog isoform X1

    See identical proteins and their annotated locations for XP_006540944.1

    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain

  6. XM_006540878.1 → XP_006540941.1  zinc finger protein 473 homolog isoform X1

    See identical proteins and their annotated locations for XP_006540941.1

    UniProtKB/Swiss-Prot
    Q8BI67, Q8BI98, Q8BIB7
    Conserved Domains (4) summary
    cd07765
    Location:23 → 63
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:485 → 888
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 471
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI67.1 GenPept UniProtKB/Swiss-Prot:Q8BI67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous