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Zfp536 zinc finger protein 536 [ Mus musculus (house mouse) ]

Gene ID: 243937, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp536provided by MGI
Official Full Name
zinc finger protein 536provided by MGI
Primary source
MGI:MGI:1926102
See related
Ensembl:ENSMUSG00000043456 AllianceGenome:MGI:1926102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf536; mKIAA0390; 9630010P11Rik
Summary
Enables retinoic acid-responsive element binding activity. Acts upstream of or within negative regulation of neuron differentiation and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human ZNF536 (zinc finger protein 536). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 1.6), CNS E14 (RPKM 1.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B2- B3; 7 24.57 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (37017448..37473733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (37318023..37774039, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38439 Neighboring gene predicted gene 28077 Neighboring gene predicted gene, 30544 Neighboring gene predicted gene, 30483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:38218361-38218562 Neighboring gene STARR-seq mESC enhancer starr_18668 Neighboring gene predicted gene, 51477 Neighboring gene STARR-seq mESC enhancer starr_18670 Neighboring gene RIKEN cDNA 4930505M18 gene Neighboring gene STARR-seq mESC enhancer starr_18671 Neighboring gene predicted gene, 22302 Neighboring gene STARR-positive B cell enhancer ABC_E8166 Neighboring gene STARR-positive B cell enhancer ABC_E6537 Neighboring gene URI1, prefoldin-like chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Qin Z, et al. Mol Cell Biol, 2009 Jul. PMID 19398580, Free PMC Article
  2. Functional genomic analysis of oligodendrocyte differentiation. Dugas JC, et al. J Neurosci, 2006 Oct 25. PMID 17065439, Free PMC Article
  3. Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene. Mattiske T, et al. Hum Mol Genet, 2016 Dec 15. PMID 27798109
  4. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Sandberg M, et al. Neuron, 2016 Sep 21. PMID 27657450, Free PMC Article
  5. Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Zhou J, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Dec. PMID 29055695

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify a novel zinc finger protein, ZNF536, that negatively regulates neuron differentiation
    Title: ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription.
  2. ZFP536 promotes the late phase of oligodendrocyte differentiation.
    Title: Functional genomic analysis of oligodendrocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid-responsive element binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 536

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404091.1 → NP_001391020.1  zinc finger protein 536 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC133950, AC140213
    UniProtKB/Swiss-Prot
    Q80U15, Q8K083
    Related
    ENSMUSP00000135068.2, ENSMUST00000176205.8

  2. NM_001404093.1 → NP_001391022.1  zinc finger protein 536 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  3. NM_001404094.1 → NP_001391023.1  zinc finger protein 536 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  4. NM_001404095.1 → NP_001391024.1  zinc finger protein 536 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  5. NM_001404096.1 → NP_001391025.1  zinc finger protein 536 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  6. NM_001404097.1 → NP_001391026.1  zinc finger protein 536 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  7. NM_001404099.1 → NP_001391028.1  zinc finger protein 536 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  8. NM_001404100.1 → NP_001391029.1  zinc finger protein 536 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133648, AC133950, AC140213

  9. NM_172385.3 → NP_759017.1  zinc finger protein 536 isoform a

    See identical proteins and their annotated locations for NP_759017.1

    Status: VALIDATED

    Source sequence(s)
    AC133950, AC140213
    Consensus CDS
    CCDS21156.1
    UniProtKB/Swiss-Prot
    Q80U15, Q8K083
    Related
    ENSMUSP00000058468.7, ENSMUST00000056338.13
    Conserved Domains (5) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam16606
    Location:657 → 737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

RNA

  1. NR_175807.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC133950
    Related
    ENSMUST00000176137.2

  2. NR_175808.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC133950

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    37017448..37473733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153106.1 → XP_036008999.1  zinc finger protein 536 isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:345 → 367
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145 → 169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:730 → 753
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 718
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  2. XM_017322250.3 → XP_017177739.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  3. XM_017322245.3 → XP_017177734.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  4. XM_036153102.1 → XP_036008995.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  5. XM_036153099.1 → XP_036008992.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  6. XM_017322247.2 → XP_017177736.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  7. XM_036153100.1 → XP_036008993.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  8. XM_036153107.1 → XP_036009000.1  zinc finger protein 536 isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:345 → 367
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145 → 169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:730 → 753
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 718
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  9. XM_036153105.1 → XP_036008998.1  zinc finger protein 536 isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:345 → 367
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145 → 169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:730 → 753
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 718
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  10. XM_017322246.2 → XP_017177735.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  11. XM_011250580.4 → XP_011248882.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  12. XM_030242573.2 → XP_030098433.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  13. XM_036153101.1 → XP_036008994.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  14. XM_017322249.3 → XP_017177738.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  15. XM_036153098.1 → XP_036008991.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  16. XM_036153104.1 → XP_036008997.1  zinc finger protein 536 isoform X2

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  17. XM_036153103.1 → XP_036008996.1  zinc finger protein 536 isoform X2

    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K083.1 GenPept UniProtKB/Swiss-Prot:Q8K083

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