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Ggn gametogenetin [ Mus musculus (house mouse) ]

Gene ID: 243897, updated on 5-Mar-2024

Summary

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Official Symbol
Ggnprovided by MGI
Official Full Name
gametogenetinprovided by MGI
Primary source
MGI:MGI:2181461
See related
Ensembl:ENSMUSG00000031493 AllianceGenome:MGI:2181461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables identical protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including double-strand break repair; embryo implantation; and gamete generation. Located in nucleolus and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; eye; gonad; and metanephros. Orthologous to human GGN (gametogenetin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 126.0) See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28869635..28873363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29168391..29173938)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAS guanyl releasing protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene sprouty-related EVH1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Neighboring gene cation channel sperm associated auxiliary subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E10433 Neighboring gene STARR-positive B cell enhancer ABC_E4913

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. Guo K, et al. J Cell Mol Med, 2018 Oct. PMID 30055035, Free PMC Article
  2. Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Jamsai D, et al. Reproduction, 2008 Jun. PMID 18502891
  3. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Hansson AS, et al. Am J Pathol, 2004 Mar. PMID 14982849, Free PMC Article
  4. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. Zhao Q, et al. Mol Reprod Dev, 2005 Sep. PMID 15892049
  5. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu B, et al. J Biol Chem, 2003 May 2. PMID 12574169

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes.
    Title: Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice.
  2. Results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos.
    Title: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear envelope NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gametogenetin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358852.1 → NP_001345781.1  gametogenetin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC164564
    Consensus CDS
    CCDS90196.1
    UniProtKB/Swiss-Prot
    Q5EBP4, Q80WI9, Q80WJ0, Q80WJ1
    Related
    ENSMUSP00000146750.2, ENSMUST00000209019.2
    Conserved Domains (1) summary
    pfam15685
    Location:2 → 672
    GGN; Gametogenetin

  2. NM_182694.2 → NP_874353.2  gametogenetin isoform 1

    See identical proteins and their annotated locations for NP_874353.2

    Status: VALIDATED

    Source sequence(s)
    BC089358
    Consensus CDS
    CCDS52168.1
    UniProtKB/TrEMBL
    G5E8M4
    Related
    ENSMUSP00000096209.3, ENSMUST00000098609.4
    Conserved Domains (1) summary
    pfam15685
    Location:38 → 708
    GGN; Gametogenetin

  3. NM_182696.3 → NP_874355.1  gametogenetin isoform 3

    See identical proteins and their annotated locations for NP_874355.1

    Status: VALIDATED

    Source sequence(s)
    AC164564
    Consensus CDS
    CCDS21067.1
    UniProtKB/Swiss-Prot
    Q80WJ1
    Related
    ENSMUSP00000033886.8, ENSMUST00000033886.8
    Conserved Domains (1) summary
    pfam15685
    Location:2 → 136
    GGN; Gametogenetin

RNA

  1. NR_154992.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164564
    Related
    ENSMUST00000208288.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28869635..28873363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539944.5 → XP_006540007.1  gametogenetin isoform X1

    UniProtKB/TrEMBL
    A0A140LI02
    Related
    ENSMUSP00000146620.2, ENSMUST00000208330.2
    Conserved Domains (1) summary
    pfam15685
    Location:15 → 685
    GGN; Gametogenetin

  2. XM_006539946.2 → XP_006540009.1  gametogenetin isoform X2

    Conserved Domains (1) summary
    pfam15685
    Location:1 → 444
    GGN; Gametogenetin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WJ1.2 GenPept UniProtKB/Swiss-Prot:Q80WJ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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