Zfp128 zinc finger protein 128 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp128provided by MGI
Official Full Name: zinc finger protein 128provided by MGI
Primary source: MGI:MGI:2389445
See related: Ensembl:ENSMUSG00000060397 AllianceGenome:MGI:2389445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf8; mZnf8; 9630016P15Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in eye. Orthologous to human ZNF8 (zinc finger protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 3.0), whole brain E14.5 (RPKM 2.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.67 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (12615105..12627349)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (12881178..12893422)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Znf8 plays a role in BMP signaling during spermatogenesis in mice
Title: Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153802.4 → NP_722497.1 zinc finger protein 8

See identical proteins and their annotated locations for NP_722497.1

Status: VALIDATED

Source sequence(s)

AK032046, AK035906, BC088998

Consensus CDS

CCDS20815.1

UniProtKB/Swiss-Prot

Q52KP6, Q8BGV5, Q8BJ50

Related

ENSMUSP00000115378.2, ENSMUST00000144578.2

Conserved Domains (6) summary

smart00349
Location:25 → 85

KRAB; krueppel associated box

COG5048
Location:198 → 401

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:256 → 276

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:464 → 486

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:25 → 64

KRAB; KRAB box

pfam13465
Location:268 → 293

zf-H2C2_2; Zinc-finger double domain