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Parp12 poly (ADP-ribose) polymerase family, member 12 [ Mus musculus (house mouse) ]

Gene ID: 243771, updated on 11-Apr-2024

Summary

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Official Symbol
Parp12provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 12provided by MGI
Primary source
MGI:MGI:2143990
See related
Ensembl:ENSMUSG00000038507 AllianceGenome:MGI:2143990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD12; PARP-12; Zc3hdc1; 9930021O16
Summary
Predicted to enable protein ADP-ribosylase activity. Predicted to be involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in nucleus. Is expressed in early conceptus; gallbladder; gut; metanephros; and reproductive system. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 28.4), colon adult (RPKM 27.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 17.85 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39063346..39095283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39086412..39118349, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene STARR-seq mESC enhancer starr_15629 Neighboring gene lysine (K)-specific demethylase 7A Neighboring gene STARR-positive B cell enhancer ABC_E3651 Neighboring gene STARR-seq mESC enhancer starr_15630 Neighboring gene STARR-positive B cell enhancer ABC_E6424 Neighboring gene predicted gene, 38794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. Li L, et al. Sci Signal, 2018 Jun 19. PMID 29921658, Free PMC Article
  2. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation. Welsby I, et al. J Biol Chem, 2014 Sep 19. PMID 25086041, Free PMC Article
  3. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Katoh M, et al. Int J Oncol, 2003 Aug. PMID 12851707
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
    Title: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
  2. PARP12 regulates mouse oocyte meiotic maturation.
    Title: PARP12 regulates mouse oocyte meiotic maturation.
  3. To screen for antiviral IFN-stimulated genes that restricted Zika virus replication, and identified PARP12 as a strong inhibitor of Zika virus replication. Findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses.
    Title: PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins.
  4. PARP12 is an interferon-induced gene with a potential role in cellular defenses against viral infections.
    Title: PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP12
Names
ADP-ribosyltransferase diphtheria toxin-like 12
poly ADP-ribose polymerase 12
poly [ADP-ribose] polymerase 12
zinc finger CCCH domain-containing protein 1
zinc finger CCCH type domain containing 1
NP_766481.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172893.3 → NP_766481.2  protein mono-ADP-ribosyltransferase PARP12

    See identical proteins and their annotated locations for NP_766481.2

    Status: VALIDATED

    Source sequence(s)
    AK036886, BC048927, BC120733
    Consensus CDS
    CCDS20019.1
    UniProtKB/Swiss-Prot
    Q0VB94, Q80VL6, Q8BZ20, Q8K333, Q8R3U2
    UniProtKB/TrEMBL
    Q3U0S1
    Related
    ENSMUSP00000039704.7, ENSMUST00000038398.7
    Conserved Domains (5) summary
    smart00356
    Location:186 → 208
    ZnF_C3H1; zinc finger
    cd01439
    Location:571 → 687
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:506 → 689
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam02825
    Location:387 → 468
    WWE; WWE domain
    cl02729
    Location:309 → 382
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39063346..39095283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ20.3 GenPept UniProtKB/Swiss-Prot:Q8BZ20

Gene LinkOut

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