Slc13a4 solute carrier family 13 (sodium/sulfate symporters), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc13a4provided by MGI
Official Full Name: solute carrier family 13 (sodium/sulfate symporters), member 4provided by MGI
Primary source: MGI:MGI:2442367
See related: Ensembl:ENSMUSG00000029843 AllianceGenome:MGI:2442367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SUT1; SUT-1; 9630060C05Rik
Summary: Predicted to be involved in anion transmembrane transport. Predicted to be integral component of membrane. Is expressed in brain meninges; choroid plexus; lung; and urethra. Orthologous to human SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 18.6), frontal lobe adult (RPKM 2.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 15.26 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (35244888..35285061, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (35267953..35308126, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Perineuronal net abnormalities in Slc13a4(+/-) mice are rescued by postnatal administration of N-acetylcysteine.
Title: Perineuronal net abnormalities in Slc13a4(+/-) mice are rescued by postnatal administration of N-acetylcysteine.
Our study identifies SLC13A4 as a critical regulator of early postnatal brain development. Haploinsufficiency of Slc13a4 leads to atypical phenotypes in mice that display a developmental origin similar to the onset of neurodevelopmental disorders in humans such as ASD.
Title: Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice.
Study describes the critical requirement of placental Slc13a4 activity for normal fetal development in mice.
Title: Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice.
Tissue distribution of mNaS2 and its cDNA and gene structures.
Title: Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): Structure and expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Slc13a4 (e-PCR), detects polymorphism
- UniSTS:547312

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sodium:sulfate symporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 13 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172892.3 → NP_766480.1 solute carrier family 13 member 4

See identical proteins and their annotated locations for NP_766480.1

Status: VALIDATED

Source sequence(s)

AK036354, AW536922

Consensus CDS

CCDS20000.1

UniProtKB/TrEMBL

Q5FWX9, Q8BZ82

Related

ENSMUSP00000031868.5, ENSMUST00000031868.5

Conserved Domains (2) summary

TIGR00785
Location:40 → 602

dass; anion transporter

cl21473
Location:31 → 607

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...