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Klre1 killer cell lectin-like receptor family E member 1 [ Mus musculus (house mouse) ]

Gene ID: 243655, updated on 8-Feb-2024

Summary

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Official Symbol
Klre1provided by MGI
Official Full Name
killer cell lectin-like receptor family E member 1provided by MGI
Primary source
MGI:MGI:2662547
See related
Ensembl:ENSMUSG00000050241 AllianceGenome:MGI:2662547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NKG2I; Klre-1
Summary
Enables identical protein binding activity and transmembrane signaling receptor activity. Acts upstream of or within natural killer cell activation; positive regulation of innate immune response; and positive regulation of interferon-gamma production. Located in external side of plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
6 F3; 6 63.41 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129536329..129562790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129559365..129585828)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52B Neighboring gene RIKEN cDNA 1700101I11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:129481855-129482155 Neighboring gene GABA type A receptor associated protein like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10411 Neighboring gene STARR-positive B cell enhancer mm9_chr6:129531448-129531748 Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily K, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice. Shimizu E, et al. Blood, 2004 Aug 1. PMID 15069013
  2. Identification of a new murine lectin-like gene in close proximity to CD94. Wilhelm BT, et al. Immunogenetics, 2003 Apr. PMID 12715246
  3. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Westgaard IH, et al. J Exp Med, 2003 Jun 2. PMID 12782717, Free PMC Article
  4. KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Saether PC, et al. J Immunol, 2008 Sep 1. PMID 18713988, Free PMC Article
  5. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. Koike J, et al. J Exp Med, 2004 Jan 5. PMID 14707119, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1
    Title: The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.
  2. mediates recognition and rejection of allogeneic target cells in the host immune system
    Title: Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within natural killer cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within stimulatory C-type lectin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily E member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381986.1 → NP_001368915.1  killer cell lectin-like receptor subfamily E member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161602
    UniProtKB/Swiss-Prot
    Q80WP0, Q8CJC7
    Conserved Domains (1) summary
    cd03593
    Location:113 → 226
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_001381987.1 → NP_001368916.1  killer cell lectin-like receptor subfamily E member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161602
    Conserved Domains (1) summary
    cl02432
    Location:113 → 158
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  3. NM_001381988.1 → NP_001368917.1  killer cell lectin-like receptor subfamily E member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161602
    Conserved Domains (1) summary
    cl02432
    Location:113 → 158
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  4. NM_153590.3 → NP_705818.3  killer cell lectin-like receptor subfamily E member 1 isoform 1

    See identical proteins and their annotated locations for NP_705818.3

    Status: VALIDATED

    Source sequence(s)
    AF306663, BG145575, BX518942
    Consensus CDS
    CCDS20589.1
    UniProtKB/Swiss-Prot
    Q80WP0, Q8CJC7
    Related
    ENSMUSP00000055779.7, ENSMUST00000053708.9
    Conserved Domains (1) summary
    cd03593
    Location:113 → 226
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129536329..129562790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506123.4 → XP_006506186.1  killer cell lectin-like receptor subfamily E member 1 isoform X2

    See identical proteins and their annotated locations for XP_006506186.1

    UniProtKB/Swiss-Prot
    Q80WP0, Q8CJC7
    Conserved Domains (1) summary
    cd03593
    Location:113 → 226
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. XM_017321589.3 → XP_017177078.1  killer cell lectin-like receptor subfamily E member 1 isoform X2

    UniProtKB/Swiss-Prot
    Q80WP0, Q8CJC7
    Conserved Domains (1) summary
    cd03593
    Location:113 → 226
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  3. XM_006506121.1 → XP_006506184.1  killer cell lectin-like receptor subfamily E member 1 isoform X1

    Conserved Domains (1) summary
    cd03593
    Location:139 → 252
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  4. XM_006506128.3 → XP_006506191.1  killer cell lectin-like receptor subfamily E member 1 isoform X3

    Conserved Domains (1) summary
    cl02432
    Location:139 → 184
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  5. XM_036166121.1 → XP_036022014.1  killer cell lectin-like receptor subfamily E member 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJC7.1 GenPept UniProtKB/Swiss-Prot:Q8CJC7

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