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A430033K04Rik RIKEN cDNA A430033K04 gene [ Mus musculus (house mouse) ]

Gene ID: 243308, updated on 27-Feb-2024

Summary

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Official Symbol
A430033K04Rikprovided by MGI
Official Full Name
RIKEN cDNA A430033K04 geneprovided by MGI
Primary source
MGI:MGI:3583896
See related
Ensembl:ENSMUSG00000056014 AllianceGenome:MGI:3583896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ObI1; ObI-1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZNF487 (zinc finger protein 487). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 4.7), CNS E18 (RPKM 4.4) and 23 other tissues See more
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Genomic context

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Location:
5 G2; 5 77.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138621121..138647179)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138622859..138648917)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700123K08 gene Neighboring gene STARR-seq mESC enhancer starr_14669 Neighboring gene STARR-positive B cell enhancer ABC_E1314 Neighboring gene zinc finger protein 68 Neighboring gene STARR-seq mESC enhancer starr_14671 Neighboring gene STARR-seq mESC enhancer starr_14672 Neighboring gene STARR-seq mESC enhancer starr_14673 Neighboring gene FAM20C, golgi associated secretory pathway kinase Neighboring gene STARR-seq mESC enhancer starr_14674 Neighboring gene forkhead box L3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a Novel Transcription Factor Required for Osteogenic Differentiation of Mesenchymal Stem Cells. Querques F, et al. Stem Cells Dev, 2019 Mar 15. PMID 30654721
  2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein OBI1
Names
osteoblast inducer-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183025.2 → NP_898846.2  zinc finger protein OBI1

    Status: VALIDATED

    Source sequence(s)
    AI842993, AK009353, BC055299, BM229635
    UniProtKB/Swiss-Prot
    E9Q8G5
    Related
    ENSMUSP00000067316.8, ENSMUST00000069862.11
    Conserved Domains (4) summary
    smart00349
    Location:16 → 75
    KRAB; krueppel associated box
    COG5048
    Location:261 → 670
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:513 → 533
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:429 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138621121..138647179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q8G5.1 GenPept UniProtKB/Swiss-Prot:E9Q8G5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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