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Slc49a3 solute carrier family 49 member 3 [ Mus musculus (house mouse) ]

Gene ID: 243197, updated on 11-Apr-2024

Summary

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Official Symbol
Slc49a3provided by MGI
Official Full Name
solute carrier family 49 member 3provided by MGI
Primary source
MGI:MGI:2442629
See related
Ensembl:ENSMUSG00000029490 AllianceGenome:MGI:2442629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfsd7; Mfsd7a; 4732482E20Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC49A3 (solute carrier family 49 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 8.0), colon adult (RPKM 6.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.11 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108588920..108598631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108441052..108450765, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Neighboring gene predicted gene, 34254 Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene predicted gene, 34319 Neighboring gene ATP synthase membrane subunit e Neighboring gene STARR-positive B cell enhancer ABC_E6360 Neighboring gene polycomb group ring finger 3 Neighboring gene ribosomal protein L34 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 49 member A3
Names
major facilitator superfamily domain containing 7
major facilitator superfamily domain containing 7A
major facilitator superfamily domain-containing protein 7
major facilitator superfamily domain-containing protein 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359977.1 → NP_001346906.1  solute carrier family 49 member A3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC158912
    Conserved Domains (1) summary
    cd06174
    Location:53 → 206
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_172883.3 → NP_766471.1  solute carrier family 49 member A3 isoform 1

    See identical proteins and their annotated locations for NP_766471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029021, AK087226
    Consensus CDS
    CCDS19511.1
    UniProtKB/Swiss-Prot
    Q505K1, Q8CE47
    Related
    ENSMUSP00000031455.4, ENSMUST00000031455.5
    Conserved Domains (2) summary
    cd06174
    Location:37 → 403
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:40 → 394
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108588920..108598631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534932.5 → XP_006534995.1  solute carrier family 49 member A3 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:32 → 392
    MFS; Major Facilitator Superfamily

  2. XM_006534933.5 → XP_006534996.1  solute carrier family 49 member A3 isoform X3

    Conserved Domains (1) summary
    cd17399
    Location:32 → 388
    MFS_MFSD7; Major facilitator superfamily domain-containing protein 7

  3. XM_036165127.1 → XP_036021020.1  solute carrier family 49 member A3 isoform X1

    Conserved Domains (1) summary
    cd17399
    Location:35 → 432
    MFS_MFSD7; Major facilitator superfamily domain-containing protein 7

  4. XM_006534934.4 → XP_006534997.1  solute carrier family 49 member A3 isoform X4

    Conserved Domains (1) summary
    cd17399
    Location:32 → 389
    MFS_MFSD7; Major facilitator superfamily domain-containing protein 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE47.1 GenPept UniProtKB/Swiss-Prot:Q8CE47

Gene LinkOut

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