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Actr3b ARP3 actin-related protein 3B [ Mus musculus (house mouse) ]

Gene ID: 242894, updated on 3-Apr-2024

Summary

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Official Symbol
Actr3bprovided by MGI
Official Full Name
ARP3 actin-related protein 3Bprovided by MGI
Primary source
MGI:MGI:2661120
See related
Ensembl:ENSMUSG00000056367 AllianceGenome:MGI:2661120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARP11; Arp3b; Arp3beta; 9630005C02
Summary
Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in main olfactory bulb; olfactory lobe; and telencephalon ventricular layer. Orthologous to several human genes including ACTR3B (actin related protein 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 22.5), frontal lobe adult (RPKM 19.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 12.35 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25964960..26055686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25759941..25850691)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 2 Neighboring gene predicted gene, 54325 Neighboring gene STARR-seq mESC enhancer starr_12674 Neighboring gene predicted gene, 42237 Neighboring gene STARR-seq mESC enhancer starr_12675 Neighboring gene predicted gene, 21655 Neighboring gene predicted gene, 21663

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Elsen GE, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431145, Free PMC Article
  2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-related protein 3B
Names
ARP3 actin-related protein 3 homolog B
actin-related protein 3-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004365.3 → NP_001004365.1  actin-related protein 3B isoform 1

    See identical proteins and their annotated locations for NP_001004365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116412
    Consensus CDS
    CCDS19136.1
    UniProtKB/Swiss-Prot
    Q641P0, Q7TSH1
    UniProtKB/TrEMBL
    Q3TGE1
    Related
    ENSMUSP00000085578.5, ENSMUST00000088244.6
    Conserved Domains (2) summary
    COG5277
    Location:1 → 410
    COG5277; Actin-related protein [Cytoskeleton]
    PTZ00280
    Location:2 → 417
    PTZ00280; Actin-related protein 3; Provisional

  2. NM_001310504.2 → NP_001297433.1  actin-related protein 3B isoform 2

    See identical proteins and their annotated locations for NP_001297433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC116412
    Consensus CDS
    CCDS80232.1
    UniProtKB/Swiss-Prot
    Q641P0
    Related
    ENSMUSP00000121629.2, ENSMUST00000128727.8
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  3. NM_001424742.1 → NP_001411671.1  actin-related protein 3B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116412

  4. NM_001424743.1 → NP_001411672.1  actin-related protein 3B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116412

  5. NM_001424744.1 → NP_001411673.1  actin-related protein 3B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116412

  6. NM_001424745.1 → NP_001411674.1  actin-related protein 3B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116412

  7. NM_001424746.1 → NP_001411675.1  actin-related protein 3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116412

  8. NM_001424749.1 → NP_001411678.1  actin-related protein 3B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC116412

  9. NM_001424750.1 → NP_001411679.1  actin-related protein 3B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC116412

  10. NM_001424751.1 → NP_001411680.1  actin-related protein 3B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC116412

  11. NM_001424752.1 → NP_001411681.1  actin-related protein 3B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC116412

RNA

  1. NR_188892.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116412

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    25964960..26055686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165122.1 → XP_036021015.1  actin-related protein 3B isoform X2

    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  2. XM_017320880.3 → XP_017176369.1  actin-related protein 3B isoform X3

    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 288
    PTZ00280; Actin-related protein 3; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641P0.1 GenPept UniProtKB/Swiss-Prot:Q641P0

Gene LinkOut

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