U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disp3 dispatched RND transporter family member 3 [ Mus musculus (house mouse) ]

Gene ID: 242748, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Disp3provided by MGI
Official Full Name
dispatched RND transporter family member 3provided by MGI
Primary source
MGI:MGI:2444403
See related
Ensembl:ENSMUSG00000041544 AllianceGenome:MGI:2444403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptchd2; RNDEu-2; G630052C06Rik
Summary
Predicted to be involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Predicted to act upstream of or within cell differentiation and cholesterol metabolic process. Predicted to be located in cytoplasm. Orthologous to human DISP3 (dispatched RND transporter family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 4.6), frontal lobe adult (RPKM 4.1) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 E2; 4 78.73 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148320890..148372653, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148236433..148288196, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene STARR-seq mESC enhancer starr_12077 Neighboring gene F-box protein 2 Neighboring gene predicted gene, 32603 Neighboring gene STARR-positive B cell enhancer ABC_E103 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene predicted gene, 23303 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene angiopoietin-like 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Peart MJ, et al. Proc Natl Acad Sci U S A, 2005 Mar 8. PMID 15738394, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein dispatched homolog 3
Names
RND-type protein RNDEu-2
patched domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083342.1 → NP_001076811.1  protein dispatched homolog 3

    Status: VALIDATED

    Source sequence(s)
    AL606919, AL645605
    Consensus CDS
    CCDS38966.1
    UniProtKB/Swiss-Prot
    A3KFU9, Q0EEE3, Q69ZL6, Q6GQX3, Q6NS63
    UniProtKB/TrEMBL
    E9QL24
    Related
    ENSMUSP00000038490.9, ENSMUST00000047720.9
    Conserved Domains (1) summary
    cl21543
    Location:440 → 570
    MMPL; MMPL family

RNA

  1. NR_149755.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK160667, AK160846, BB840401, BC072569, BM949407

  2. NR_154985.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606919, BB840401, BC070441

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148320890..148372653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538859.5 → XP_006538922.1  protein dispatched homolog 3 isoform X3

    Conserved Domains (1) summary
    COG1033
    Location:467 → 637
    COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

  2. XM_011250254.4 → XP_011248556.1  protein dispatched homolog 3 isoform X1

    Conserved Domains (1) summary
    COG1033
    Location:371 → 568
    COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

  3. XM_036164132.1 → XP_036020025.1  protein dispatched homolog 3 isoform X2

    Conserved Domains (1) summary
    COG1033
    Location:371 → 568
    COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

RNA

  1. XR_390748.5 RNA Sequence

  2. XR_004941903.1 RNA Sequence

  3. XR_004941902.1 RNA Sequence

  4. XR_004941901.1 RNA Sequence

  5. XR_004941900.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KFU9.1 GenPept UniProtKB/Swiss-Prot:A3KFU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous