U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Padi6 peptidyl arginine deiminase, type VI [ Mus musculus (house mouse) ]

Gene ID: 242726, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Padi6provided by MGI
Official Full Name
peptidyl arginine deiminase, type VIprovided by MGI
Primary source
MGI:MGI:2655198
See related
Ensembl:ENSMUSG00000040935 AllianceGenome:MGI:2655198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P75; Pad6; ePAD; Padi5
Summary
Enables protein-arginine deiminase activity. Involved in embryonic cleavage. Acts upstream of or within cellular protein metabolic process; cytoplasm organization; and cytoskeleton organization. Located in cortical granule and intermediate filament cytoskeleton. Is expressed in 2-cell stage embryo; ileum; and reproductive system. Human ortholog(s) of this gene implicated in infertility. Orthologous to human PADI6 (peptidyl arginine deiminase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward ovary adult (RPKM 37.0) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D3; 4 72.26 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140454666..140469954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140727355..140742643, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6247 Neighboring gene predicted gene 13025 Neighboring gene STARR-seq mESC enhancer starr_11875 Neighboring gene regulator of chromosome condensation 2 Neighboring gene STARR-positive B cell enhancer ABC_E8005 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140306464-140306665 Neighboring gene peptidyl arginine deiminase, type IV Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140338844-140339025 Neighboring gene predicted gene, 52482 Neighboring gene peptidyl arginine deiminase, type III

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Kan R, et al. Dev Biol, 2011 Feb 15. PMID 21147087, Free PMC Article
  2. Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices. Liu X, et al. Cell Cycle, 2017 Feb 16. PMID 27929740, Free PMC Article
  3. Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Esposito G, et al. Mol Cell Endocrinol, 2007 Jul 15. PMID 17587491
  4. Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development. Liu M, et al. Reprod Biol Endocrinol, 2005 Sep 1. PMID 16137333, Free PMC Article
  5. ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Wright PW, et al. Dev Biol, 2003 Apr 1. PMID 12654293

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos.
    Title: A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos.
  2. mRNAs, possibly in a complex with MSY2 and PADI6, are bound in the cytoplasmic lattices (CPLs) and may play a role in securing the mRNA-MSY2 complex to the CPLs.
    Title: Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.
  3. Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest
    Title: Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
  4. PADI6/cytoplasmic lattice superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement.
    Title: Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.
  5. Phosphorylation and/or YWHA binding may serve as a means of intracellular PADI6 regulation.
    Title: Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice.
  6. embryonic genome activation (EGA) is defective in Padi6-/- two-cell embryos
    Title: Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo.
  7. Inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected.
    Title: Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility.
  8. localized to egg cytoplasmic sheets; possible role for ePAD in cytoskeletal reorganization in the egg and early embryo
    Title: ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-arginine deiminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine deiminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytoplasm organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic cleavage IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation by machinery localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-arginine deiminase type-6
Names
arginine deiminase-like protein
egg and embryo abundant PAD
peptidyl arginine deiminase, egg and embryo abundant
peptidylarginine deiminase VI
protein-arginine deiminase type VI
NP_694746.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153106.2 → NP_694746.2  protein-arginine deiminase type-6

    See identical proteins and their annotated locations for NP_694746.2

    Status: VALIDATED

    Source sequence(s)
    AK139616, BC053724, CJ202890
    Consensus CDS
    CCDS38936.1
    UniProtKB/Swiss-Prot
    Q75WC6, Q8K3V4
    Related
    ENSMUSP00000044044.5, ENSMUST00000038749.11
    Conserved Domains (3) summary
    pfam03068
    Location:283 → 679
    PAD; Protein-arginine deiminase (PAD)
    pfam08526
    Location:1 → 112
    PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
    pfam08527
    Location:114 → 262
    PAD_M; Protein-arginine deiminase (PAD) middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140454666..140469954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3V4.2 GenPept UniProtKB/Swiss-Prot:Q8K3V4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous