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Dlgap3 DLG associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 242667, updated on 11-Apr-2024

Summary

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Official Symbol
Dlgap3provided by MGI
Official Full Name
DLG associated protein 3provided by MGI
Primary source
MGI:MGI:3039563
See related
Ensembl:ENSMUSG00000042388 AllianceGenome:MGI:3039563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAP3; DAP-3; Prpl8; Sapap3
Summary
Enables amyloid-beta binding activity. Involved in modification of synaptic structure. Located in glutamatergic synapse and neuromuscular junction. Is active in cholinergic synapse and postsynaptic specialization. Orthologous to human DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 35.9), frontal lobe adult (RPKM 29.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 61.33 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (127062090..127130815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127168305..127237022)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35B Neighboring gene STARR-seq mESC enhancer starr_11422 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11423 Neighboring gene STARR-seq mESC enhancer starr_11425 Neighboring gene STARR-seq mESC enhancer starr_11428 Neighboring gene predicted gene, 52707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:126920065-126920248 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:126920954-126921137 Neighboring gene small integral membrane protein 12 Neighboring gene predicted gene, 22221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Davis GL, et al. Nat Commun, 2021 Oct 15. PMID 34654803, Free PMC Article
  2. Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice. Ramírez-Armenta KI, et al. Neuropsychopharmacology, 2022 Jan. PMID 34417544, Free PMC Article
  3. Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice. Manning EE, et al. Sci Rep, 2021 May 3. PMID 33941812, Free PMC Article
  4. A cross-species assessment of behavioral flexibility in compulsive disorders. Benzina N, et al. Commun Biol, 2021 Jan 21. PMID 33479495, Free PMC Article
  5. Dysfunction of Orbitofrontal GABAergic Interneurons Leads to Impaired Reversal Learning in a Mouse Model of Obsessive-Compulsive Disorder. Yang Z, et al. Curr Biol, 2021 Jan 25. PMID 33188744

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
    Title: Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
  2. Valence processing alterations in SAPAP3 knockout mice and human OCD.
    Title: Valence processing alterations in SAPAP3 knockout mice and human OCD.
  3. SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
    Title: SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
  4. Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
    Title: Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
  5. Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
    Title: Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
  6. Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
    Title: Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
  7. Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
    Title: Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
  8. Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study.
    Title: Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study.
  9. Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.
    Title: Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.
  10. Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice.
    Title: Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modification of postsynaptic structure IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cholinergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disks large-associated protein 3
Names
PSD-95/SAP90-binding protein 3
SAP90/PSD 95 associated protein 3
discs, large homolog-associated protein 3
prion protein ligand 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302081.2 → NP_001289010.1  disks large-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001289010.1

    Status: VALIDATED

    Source sequence(s)
    AL606984
    Consensus CDS
    CCDS18665.1
    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61
    Related
    ENSMUSP00000101700.3, ENSMUST00000106094.9
    Conserved Domains (2) summary
    PHA03418
    Location:515 → 607
    PHA03418; hypothetical E4 protein; Provisional
    pfam03359
    Location:626 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_001426291.1 → NP_001413220.1  disks large-associated protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606984
    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61

  3. NM_001426292.1 → NP_001413221.1  disks large-associated protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606984
    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61

  4. NM_001426293.1 → NP_001413222.1  disks large-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606984
    UniProtKB/TrEMBL
    B1AS06

  5. NM_001426294.1 → NP_001413223.1  disks large-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606984
    UniProtKB/TrEMBL
    B1AS06

  6. NM_001426295.1 → NP_001413224.1  disks large-associated protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606984

  7. NM_198618.6 → NP_941020.1  disks large-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_941020.1

    Status: VALIDATED

    Source sequence(s)
    AL606984
    Consensus CDS
    CCDS18665.1
    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61
    Related
    ENSMUSP00000039724.8, ENSMUST00000046659.14
    Conserved Domains (2) summary
    PHA03418
    Location:515 → 607
    PHA03418; hypothetical E4 protein; Provisional
    pfam03359
    Location:626 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    127062090..127130815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164130.1 → XP_036020023.1  disks large-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61
    Conserved Domains (2) summary
    PHA03418
    Location:515 → 607
    PHA03418; hypothetical E4 protein; Provisional
    pfam03359
    Location:626 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_011240537.3 → XP_011238839.1  disks large-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011238839.1

    UniProtKB/Swiss-Prot
    Q6PDX0, Q6PFD5, Q6XBF2
    UniProtKB/TrEMBL
    Q3TY61
    Conserved Domains (2) summary
    PHA03418
    Location:515 → 607
    PHA03418; hypothetical E4 protein; Provisional
    pfam03359
    Location:626 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFD5.1 GenPept UniProtKB/Swiss-Prot:Q6PFD5

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