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Slc35d1 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 [ Mus musculus (house mouse) ]

Gene ID: 242585, updated on 11-Apr-2024

Summary

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Official Symbol
Slc35d1provided by MGI
Official Full Name
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1provided by MGI
Primary source
MGI:MGI:2140361
See related
Ensembl:ENSMUSG00000028521 AllianceGenome:MGI:2140361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UGTREL7; mKIAA0260; C330011J09
Summary
Enables pyrimidine nucleotide-sugar transmembrane transporter activity. Acts upstream of or within chondroitin sulfate biosynthetic process; embryonic skeletal system development; and pyrimidine nucleotide-sugar transmembrane transport. Located in endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; gallbladder; gut; and reproductive system. Used to study schneckenbecken dysplasia. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to human SLC35D1 (solute carrier family 35 member D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 5.4), limb E14.5 (RPKM 3.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C6; 4 47.43 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (103027846..103078208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103170649..103222269, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene insulin-like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102737628-102737949 Neighboring gene MEIR1 treanscription regulator Neighboring gene STARR-seq mESC enhancer starr_10936 Neighboring gene RIKEN cDNA 4921539E11 gene Neighboring gene STARR-seq mESC enhancer starr_10938 Neighboring gene STARR-seq mESC enhancer starr_10939 Neighboring gene RIKEN cDNA 4930456L15 gene Neighboring gene predicted gene, 36523

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Hiraoka S, et al. Nat Med, 2007 Nov. PMID 17952091
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficient mice develop a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures.
    Title: Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0260

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucuronic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine nucleotide-sugar transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-sugar transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyrimidine nucleotide-sugar transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleotide-sugar transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleotide sugar transporter SLC35D1
Names
UDP-GlcA/UDP-GalNAc transporter
UDP-galactose transporter-related protein 7
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
solute carrier family 35 member D1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356276.1 → NP_001343205.1  nucleotide sugar transporter SLC35D1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK049180, AK049462, AK140305, BY782314, CO039020
    UniProtKB/Swiss-Prot
    A2AKQ0, Q3TE90, Q5DU40, Q8BKX2, Q8BX24
    UniProtKB/TrEMBL
    A0A217FL58
    Related
    ENSMUSP00000037617.7, ENSMUST00000036195.13
    Conserved Domains (1) summary
    COG5070
    Location:49 → 329
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  2. NM_177732.5 → NP_808400.1  nucleotide sugar transporter SLC35D1 isoform 2

    See identical proteins and their annotated locations for NP_808400.1

    Status: VALIDATED

    Source sequence(s)
    AK049180, AK049462, AK140305, CO039020
    Consensus CDS
    CCDS18409.1
    UniProtKB/TrEMBL
    A0A217FL58
    Related
    ENSMUSP00000122124.2, ENSMUST00000150285.8
    Conserved Domains (1) summary
    COG5070
    Location:49 → 240
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    103027846..103078208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503079.5 → XP_006503142.1  nucleotide sugar transporter SLC35D1 isoform X1

    UniProtKB/TrEMBL
    A0A217FL58
    Conserved Domains (1) summary
    COG5070
    Location:49 → 303
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. XR_004941897.1 RNA Sequence

  2. XR_004941898.1 RNA Sequence

  3. XR_376320.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AKQ0.2 GenPept UniProtKB/Swiss-Prot:A2AKQ0

Gene LinkOut

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