Raver2 ribonucleoprotein, PTB-binding 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Raver2provided by MGI
Official Full Name: ribonucleoprotein, PTB-binding 2provided by MGI
Primary source: MGI:MGI:2443623
See related: Ensembl:ENSMUSG00000035275 AllianceGenome:MGI:2443623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430091O22Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including central nervous system; lung; metanephros; and neural ectoderm. Orthologous to human RAVER2 (ribonucleoprotein, PTB binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 9.6), limb E14.5 (RPKM 8.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.98 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (100926235..101009567)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (101069038..101152370)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The conserved mode of polypyrimidine tract-binding protein binding suggests that Raver2, like Raver1, may function as a modulator of PTB activity.
Title: A conserved peptide motif in Raver2 mediates its interaction with the polypyrimidine tract-binding protein.
Raver2 was identified as a novel member of the hnRNP family, it interacts with PTB/hnRNPI.
Title: Raver2, a new member of the hnRNP family.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960307 (e-PCR)
- UniSTS:159262

Raver2 (e-PCR), detects polymorphism
- UniSTS:479148

Raver2 (e-PCR), detects polymorphism
- UniSTS:526022

RH129388 (e-PCR)
- UniSTS:212695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribonucleoprotein PTB-binding 2

Names: protein raver-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183024.2 → NP_898845.1 ribonucleoprotein PTB-binding 2

See identical proteins and their annotated locations for NP_898845.1

Status: VALIDATED

Source sequence(s)

AL627251

Consensus CDS

CCDS18392.1

UniProtKB/Swiss-Prot

B1ASP1, Q7TPD6

Related

ENSMUSP00000043142.9, ENSMUST00000038463.15

Conserved Domains (2) summary

cd12666
Location:132 → 208

RRM2_RAVER2; RNA recognition motif 2 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)

cl17169
Location:218 → 314

RRM_SF; RNA recognition motif (RRM) superfamily