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Klhl9 kelch-like 9 [ Mus musculus (house mouse) ]

Gene ID: 242521, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl9provided by MGI
Official Full Name
kelch-like 9provided by MGI
Primary source
MGI:MGI:2180122
See related
Ensembl:ENSMUSG00000070923 AllianceGenome:MGI:2180122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1354; 8030469P05; C530050O22Rik
Summary
Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to act upstream of or within cell division. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in midbody. Is expressed in central nervous system; male reproductive system; neural retina; and urinary system. Orthologous to human KLHL9 (kelch like family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
4 C4; 4 42.02 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (88636529..88640745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (88718292..88722508, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interferon alpha B Neighboring gene interferon-alpha 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4637 Neighboring gene predicted gene 13274 Neighboring gene STARR-seq mESC enhancer starr_10728 Neighboring gene predicted gene 13271

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1354

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172871.2 → NP_766459.2  kelch-like protein 9

    See identical proteins and their annotated locations for NP_766459.2

    Status: VALIDATED

    Source sequence(s)
    AL928605
    Consensus CDS
    CCDS38800.1
    UniProtKB/Swiss-Prot
    Q505G5, Q6ZPT1
    UniProtKB/TrEMBL
    Q8C7P1
    Related
    ENSMUSP00000092602.3, ENSMUST00000094993.3
    Conserved Domains (6) summary
    smart00612
    Location:400 → 446
    Kelch; Kelch domain
    PHA03098
    Location:50 → 593
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:337 → 385
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:40 → 146
    BTB; BTB/POZ domain
    pfam01344
    Location:336 → 386
    Kelch_1; Kelch motif
    pfam07707
    Location:154 → 255
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    88636529..88640745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPT1.2 GenPept UniProtKB/Swiss-Prot:Q6ZPT1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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