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Rasef RAS and EF hand domain containing [ Mus musculus (house mouse) ]

Gene ID: 242505, updated on 11-Apr-2024

Summary

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Official Symbol
Rasefprovided by MGI
Official Full Name
RAS and EF hand domain containingprovided by MGI
Primary source
MGI:MGI:2448565
See related
Ensembl:ENSMUSG00000043003 AllianceGenome:MGI:2448565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAB45
Summary
Predicted to enable GDP binding activity; GTP binding activity; and identical protein binding activity. Predicted to be active in cytosol and perinuclear region of cytoplasm. Orthologous to human RASEF (RAS and EF-hand domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 11.0), stomach adult (RPKM 6.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C3; 4 36.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (73632814..73709382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (73714577..73791236, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 family member 2 Neighboring gene Myb/SANT DNA binding domain containing 5 family member 1 Neighboring gene predicted gene 11240 Neighboring gene Myb/SANT DNA binding domain containing 5 family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Oshita H, et al. Mol Cancer Res, 2013 Aug. PMID 23686708
  2. Testis-Specific GTPase (TSG): An oligomeric protein. Kumar S, et al. BMC Genomics, 2016 Oct 10. PMID 27724860, Free PMC Article
  3. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras and EF-hand domain-containing protein homolog
Names
testis-specific GTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017427.1 → NP_001017427.1  ras and EF-hand domain-containing protein homolog isoform 1

    See identical proteins and their annotated locations for NP_001017427.1

    Status: VALIDATED

    Source sequence(s)
    AK132691, BB616033
    Consensus CDS
    CCDS18281.1
    UniProtKB/Swiss-Prot
    B2RQ59, Q5RI75, Q5RI76
    Related
    ENSMUSP00000062771.7, ENSMUST00000058292.13
    Conserved Domains (2) summary
    cd00154
    Location:429 → 593
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:27 → 258
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001404961.1 → NP_001391890.1  ras and EF-hand domain-containing protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX294159
    UniProtKB/TrEMBL
    A0A1Y7VIT3
    Related
    ENSMUSP00000152127.2, ENSMUST00000222414.2

  3. NM_001404962.1 → NP_001391891.1  ras and EF-hand domain-containing protein homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX294159
    Related
    ENSMUSP00000099901.3, ENSMUST00000102837.3

  4. NM_001404963.1 → NP_001391892.1  ras and EF-hand domain-containing protein homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX294159
    UniProtKB/TrEMBL
    A0A1D8RIR4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    73632814..73709382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320201.2 → XP_017175690.1  ras and EF-hand domain-containing protein homolog isoform X3

    UniProtKB/Swiss-Prot
    B2RQ59, Q5RI75, Q5RI76
    Conserved Domains (2) summary
    cd00154
    Location:429 → 593
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:27 → 258
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006537927.3 → XP_006537990.1  ras and EF-hand domain-containing protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006537990.1

    UniProtKB/TrEMBL
    A0A1D8RIR4
    Conserved Domains (2) summary
    cd00154
    Location:332 → 496
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:9 → 154
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RI75.1 GenPept UniProtKB/Swiss-Prot:Q5RI75

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