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Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 242425, updated on 21-Apr-2024

Summary

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Official Symbol
Gabbr2provided by MGI
Official Full Name
gamma-aminobutyric acid type B receptor subunit 2provided by MGI
Primary source
MGI:MGI:2386030
See related
Ensembl:ENSMUSG00000039809 AllianceGenome:MGI:2386030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gb2; Gm425; Gpr51; GABABR2
Summary
Predicted to enable G protein-coupled GABA receptor activity and protein heterodimerization activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway and neuron-glial cell signaling. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm and neuron projection. Is expressed in brain; lens; lens epithelium; lens fiber; and lens vesicle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 32.0), cerebellum adult (RPKM 28.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 25.18 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46662318..46991714, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46662318..46991714, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31850 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 42281 Neighboring gene STARR-seq mESC enhancer starr_10135 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47002653-47002836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47023500-47023609 Neighboring gene STARR-seq mESC enhancer starr_10138 Neighboring gene STARR-positive B cell enhancer mm9_chr4:47033511-47033812 Neighboring gene predicted gene 568 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice. Heskin-Sweezie R, et al. Neuroscience, 2010 Aug 11. PMID 20394801, Free PMC Article
  2. Compartmentation of GABA B receptor2 expression in the mouse cerebellar cortex. Chung SH, et al. Cerebellum, 2008. PMID 18418671
  3. Presynaptic GABA(B) receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus. Irie T, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18190780
  4. Postnatal development of GABAB-receptor-mediated modulation of potassium currents in brainstem respiratory network of mouse. Pfeiffer A, et al. Respir Physiol Neurobiol, 2007 Aug 15. PMID 17428748
  5. The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Thuault SJ, et al. Biochem Pharmacol, 2004 Oct 15. PMID 15451409

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-330 Directs Downregulation of the GABABR2 in the Pathogenesis of Pancreatic Cancer Pain.
    Title: MicroRNA-330 Directs Downregulation of the GABA(B)R2 in the Pathogenesis of Pancreatic Cancer Pain.
  2. Reelin signaling modulates GABAB receptor function in the neocortex.
    Title: Reelin signaling modulates GABA(B) receptor function in the neocortex.
  3. GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
    Title: GABAergic input through GABA(B) receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
  4. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC
    Title: Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression.
  5. GABABR2 has a role as a regulator of glutamine synthetase stability
    Title: Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by γ-aminobutyric type B receptors.
  6. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
    Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
  7. Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum.
    Title: A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum.
  8. Gabbr1 and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers
    Title: A transcriptional study in mice with different ethanol-drinking profiles: possible involvement of the GABA(B) receptor.
  9. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone.
    Title: Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone.
  10. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 protein levels in mouse brains during postnatal development in vivo
    Title: Gradual downregulation of protein expression of the partner GABA(B)R2 subunit during postnatal brain development in mice defective of GABA(B)R1 subunit.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron-glial cell signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, GABAergic NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of G protein-coupled GABA receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of G protein-coupled receptor heterodimeric complex ISO
Inferred from Sequence Orthology
more info
  
part_of GABA receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid type B receptor subunit 2
Names
gamma-aminobutyric acid (GABA) B receptor, 2
ortholog of human G protein-coupled receptor 51 GPR51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081141.2 → NP_001074610.1  gamma-aminobutyric acid type B receptor subunit 2 precursor

    See identical proteins and their annotated locations for NP_001074610.1

    Status: VALIDATED

    Source sequence(s)
    AL772399, AL831741, AL844224, BX005247, BX571848
    Consensus CDS
    CCDS38758.1
    UniProtKB/Swiss-Prot
    A2AL05, Q80T41
    Related
    ENSMUSP00000103378.3, ENSMUST00000107749.4
    Conserved Domains (4) summary
    PRK03992
    Location:785 → 863
    PRK03992; proteasome-activating nucleotidase; Provisional
    cd15294
    Location:479 → 748
    7tmC_GABA-B-R2; gamma-aminobutyric acid type B receptor subunit 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam18455
    Location:778 → 816
    GBR2_CC; Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain
    cd06366
    Location:57 → 459
    PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46662318..46991714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T41.2 GenPept UniProtKB/Swiss-Prot:Q80T41

Gene LinkOut

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