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Dcaf10 DDB1 and CUL4 associated factor 10 [ Mus musculus (house mouse) ]

Gene ID: 242418, updated on 5-Mar-2024

Summary

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Official Symbol
Dcaf10provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 10provided by MGI
Primary source
MGI:MGI:2140179
See related
Ensembl:ENSMUSG00000035572 AllianceGenome:MGI:2140179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr32
Summary
Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and immune system. Orthologous to human DCAF10 (DDB1 and CUL4 associated factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 5.1), ovary adult (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dcaf10 in Genome Data Viewer
Location:
4 B1; 4 23.87 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45340764..45379732)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45340976..45379732)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45354747-45355003 Neighboring gene predicted gene, 31017 Neighboring gene predicted gene 12585 Neighboring gene STARR-seq mESC enhancer starr_10095 Neighboring gene solute carrier family 25, member 51 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45421840-45422023 Neighboring gene STARR-seq mESC enhancer starr_10098 Neighboring gene predicted gene, 54219 Neighboring gene src homology 2 domain-containing transforming protein B Neighboring gene STARR-positive B cell enhancer ABC_E6172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45477486-45477669 Neighboring gene STARR-seq mESC enhancer starr_10101 Neighboring gene VISTA enhancer mm1668

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
  2. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11993, MGC103038

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 10
Names
WD repeat domain 32
WD repeat-containing protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153167.2 → NP_694807.2  DDB1- and CUL4-associated factor 10

    See identical proteins and their annotated locations for NP_694807.2

    Status: VALIDATED

    Source sequence(s)
    AK083428, AL772376, BX526643, BY732400, CN533345
    Consensus CDS
    CCDS38754.1
    UniProtKB/Swiss-Prot
    A2AKB9, A2AKV8, Q3TNI7, Q5U4G6, Q8BHQ2, Q8BHS1, Q8BHX4, Q8K3A5
    Related
    ENSMUSP00000117082.2, ENSMUST00000155551.8
    Conserved Domains (4) summary
    smart00320
    Location:524 → 562
    WD40; WD40 repeats
    COG2319
    Location:178 → 326
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:179 → 214
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:171 → 326
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45340764..45379732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537912.5 → XP_006537975.1  DDB1- and CUL4-associated factor 10 isoform X1

    Conserved Domains (1) summary
    smart00320
    Location:458 → 496
    WD40; WD40 repeats
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AKB9.1 GenPept UniProtKB/Swiss-Prot:A2AKB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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