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Pm20d2 peptidase M20 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 242377, updated on 5-Mar-2024

Summary

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Official Symbol
Pm20d2provided by MGI
Official Full Name
peptidase M20 domain containing 2provided by MGI
Primary source
MGI:MGI:2685270
See related
Ensembl:ENSMUSG00000054659 AllianceGenome:MGI:2685270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm424; Acy1l2
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of cellular protein metabolic process. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 11.4), adrenal adult (RPKM 9.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Pm20d2 in Genome Data Viewer
Location:
4 A5; 4 14.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33170309..33189732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33170401..33189737, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33159852-33160053 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene predicted gene 11930 Neighboring gene serine and arginine-rich splicing factor 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. Veiga-da-Cunha M, et al. J Biol Chem, 2014 Jul 11. PMID 24891507, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates.
    Title: Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables para-aminobenzoyl-glutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in folic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
NOT is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
xaa-Arg dipeptidase
Names
aminoacylase 1-like 2
aminoacylase-1-like protein 2
peptidase M20 domain-containing protein 2
NP_001030039.2
NP_001406369.1
NP_001406370.1
NP_001406371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034867.3 → NP_001030039.2  xaa-Arg dipeptidase isoform 2

    See identical proteins and their annotated locations for NP_001030039.2

    Status: VALIDATED

    Source sequence(s)
    AL670464
    Consensus CDS
    CCDS51136.1
    UniProtKB/Swiss-Prot
    A3KG59, Q3ULU7
    Related
    ENSMUSP00000095783.3, ENSMUST00000098181.9
    Conserved Domains (2) summary
    cd05672
    Location:30 → 401
    M20_ACY1L2_like; M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily
    COG1473
    Location:34 → 389
    AbgB; Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]

  2. NM_001419440.1 → NP_001406369.1  xaa-Arg dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670464

  3. NM_001419441.1 → NP_001406370.1  xaa-Arg dipeptidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670464
    Related
    ENSMUSP00000113669.2, ENSMUST00000119167.2

  4. NM_001419442.1 → NP_001406371.1  xaa-Arg dipeptidase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670464

RNA

  1. NR_185084.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    33170309..33189732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941890.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KG59.1 GenPept UniProtKB/Swiss-Prot:A3KG59

Gene LinkOut

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