Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp6v0d2provided by MGI
Official Full Name: ATPase, H+ transporting, lysosomal V0 subunit D2provided by MGI
Primary source: MGI:MGI:1924415
See related: Ensembl:ENSMUSG00000028238 AllianceGenome:MGI:1924415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V-ATPase; 1620401A02Rik
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to be involved in vacuolar acidification and vacuolar transport. Predicted to act upstream of or within ion transport. Located in early endosome. Is expressed in several structures, including alimentary system; limb; metanephros; respiratory system; and skeleton. Orthologous to human ATP6V0D2 (ATPase H+ transporting V0 subunit d2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 4.2), genital fat pad adult (RPKM 2.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 7.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (19876838..19922566, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (19876838..19922566, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
Title: Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
Upregulation of ATP6V0D2 benefits intracellular survival of Leishmania donovani in erythrocytes-engulfing macrophages.
Title: Upregulation of ATP6V0D2 benefits intracellular survival of Leishmania donovani in erythrocytes-engulfing macrophages.
Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet beta-cell function.
Title: Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet β-cell function.
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr[682]-phosphorylated APP betaCTF.
Title: Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP βCTF.
Leishmania infection-induced multinucleated giant cell formation via upregulation of ATP6V0D2 expression.
Title: Leishmania infection-induced multinucleated giant cell formation via upregulation of ATP6V0D2 expression.
Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1.
Title: Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1.
Role of V-ATPase a3-Subunit in Mouse CTL Function.
Title: Role of V-ATPase a3-Subunit in Mouse CTL Function.
Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization.
Title: Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization.
Atp6v0d2-deficient macrophages have augmented mitochondrial damage, enhanced inflammasome activation and reduced clearance of Salmonella typhimurium. The susceptibility of atp6v0d2 knockout mice to DSS-induced colitis and Salmonella typhimurium-induced death, highlights the in vivo significance of ATP6V0D2-mediated autophagosome-lysosome fusion.
Title: The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
The authors identified that ATP6V0d2 mediates leucine-induced mTORC1 activation in macrophages, which further regulates macrophage differentiation.
Title: ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Atp6v0d2 (e-PCR), detects polymorphism
- UniSTS:498420

AI324824 (e-PCR)
- UniSTS:159224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: V-type proton ATPase subunit d 2

Names: V-ATPase subunit d 2; osteoclast-specific vacuolar ATP synthase; vacuolar proton pump subunit d 2; vacuolar proton-translocating ATPase d subunit d2

NP_780615.2

EC 7.1.2.2

XP_017175683.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175406.3 → NP_780615.2 V-type proton ATPase subunit d 2

See identical proteins and their annotated locations for NP_780615.2

Status: VALIDATED

Source sequence(s)

AK075745, AK137586, AY517482

Consensus CDS

CCDS17994.1

UniProtKB/Swiss-Prot

Q3TDQ6, Q5I0V5, Q80SY3, Q8BTL3, Q8BW16

Related

ENSMUSP00000029900.6, ENSMUST00000029900.6

Conserved Domains (2) summary

COG1527
Location:14 → 350

NtpC; Archaeal/vacuolar-type H+-ATPase subunit C/Vma6 [Energy production and conversion]

pfam01992
Location:16 → 338

vATP-synt_AC39; ATP synthase (C/AC39) subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

19876838..19922566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320194.3 → XP_017175683.1 V-type proton ATPase subunit d 2 isoform X1

Conserved Domains (1) summary

pfam01992
Location:1 → 234

vATP-synt_AC39; ATP synthase (C/AC39) subunit