U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnai3 dynein axonemal intermediate chain 3 [ Mus musculus (house mouse) ]

Gene ID: 242253, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Dnai3provided by MGI
Official Full Name
dynein axonemal intermediate chain 3provided by MGI
Primary source
MGI:MGI:3045269
See related
Ensembl:ENSMUSG00000043020 AllianceGenome:MGI:3045269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ida7; IC140; Wdr63; 4931433A13Rik
Summary
Predicted to enable Arp2/3 complex binding activity; dynein heavy chain binding activity; and dynein light chain binding activity. Involved in positive regulation of osteoblast differentiation. Part of axonemal dynein complex. Is expressed in choroid plexus; lung epithelium; node; and sensory organ. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.4), lung adult (RPKM 1.2) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 H2; 3 71.03 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145746281..145813855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146040526..146108100, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09212 Neighboring gene synapse defective 1, Rho GTPase, homolog 2 (C. elegans) Neighboring gene predicted gene, 40166 Neighboring gene STARR-seq mESC enhancer starr_09216 Neighboring gene predicted gene, 35409 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:145726222-145726405 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145770955-145771256 Neighboring gene mucolipin 3 Neighboring gene predicted gene, 25627 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145797888-145798188 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145815297-145815597 Neighboring gene mucolipin 2 Neighboring gene STARR-positive B cell enhancer ABC_E9580 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145847906-145848206

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla. Diao S, et al. J Endod, 2015 Feb. PMID 25498833
  2. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis. Zhao K, et al. EMBO Rep, 2020 Apr 3. PMID 32128961, Free PMC Article
  3. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Young SA, et al. Int J Mol Sci, 2015 Oct 16. PMID 26501274, Free PMC Article
  4. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
  5. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.
    Title: WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal intermediate chain 3
Names
WD repeat domain 63
WD repeat-containing protein 63
dynein intermediate chain 3, axonemal

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172864.3 → NP_766452.2  dynein axonemal intermediate chain 3

    See identical proteins and their annotated locations for NP_766452.2

    Status: VALIDATED

    Source sequence(s)
    AK029903, BX631982
    Consensus CDS
    CCDS17899.2
    UniProtKB/Swiss-Prot
    B2RY71
    Related
    ENSMUSP00000124475.2, ENSMUST00000160285.2
    Conserved Domains (1) summary
    COG2319
    Location:384 → 532
    WD40; WD40 repeat [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145746281..145813855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319579.3 → XP_017175068.1  dynein axonemal intermediate chain 3 isoform X1

    UniProtKB/TrEMBL
    Q8C0T4
    Conserved Domains (1) summary
    COG2319
    Location:198 → 346
    WD40; WD40 repeat [General function prediction only]

RNA

  1. XR_867216.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RY71.1 GenPept UniProtKB/Swiss-Prot:B2RY71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous