Bank1 B cell scaffold protein with ankyrin repeats 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bank1provided by MGI
Official Full Name: B cell scaffold protein with ankyrin repeats 1provided by MGI
Primary source: MGI:MGI:2442120
See related: Ensembl:ENSMUSG00000037922 AllianceGenome:MGI:2442120
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BANK; AVIEF; A530094C12Rik
Summary: Predicted to enable enzyme binding activity; signaling adaptor activity; and signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of B cell activation; negative regulation of gene expression; and regulation of intracellular signal transduction. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and systemic scleroderma (multiple). Orthologous to human BANK1 (B cell scaffold protein with ankyrin repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 7.9), mammary gland adult (RPKM 2.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 63.04 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (135759124..136031902, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (136053363..136326141, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells.
Title: BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells.
B cell responses were enhanced due to decreased B cell scaffold protein with ankyrin repeats 1 (BANK1) levels in collagen-induced arthritis (CIA) mice.
Title: BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen-induced arthritis.
Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development
Title: Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development.
The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway.
Title: ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
Following CpG stimulation of B-cells, BANK1 loss reduced p38 phosphorylation (but not ERK or JNK), IL-6 secretion, & MNK1/2 and eIF4E phosphorylation. It had no effect on IL-6 mRNA stability. BANK1 does not affect release of eIF4E by phospho-4E-BP1.
Title: BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.
BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses.
Title: BANK negatively regulates Akt activation and subsequent B cell responses.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488509

AI451642 (e-PCR)
- UniSTS:159194

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of B cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell scaffold protein with ankyrin repeats

Names: B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033350.3 → NP_001028522.2 B-cell scaffold protein with ankyrin repeats isoform 1

See identical proteins and their annotated locations for NP_001028522.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA175345, AA177599, AA178225, AC101978, AK041039, AK041071, AK041242, BE848854, BY107051, BY235799

Consensus CDS

CCDS38645.1

UniProtKB/Swiss-Prot

E9QMV3, Q3U178, Q80VH0, Q8BRV6, Q8BRY8

UniProtKB/TrEMBL

Q0P699

Related

ENSMUSP00000035484.9, ENSMUST00000041577.13

Conserved Domains (2) summary

pfam14545
Location:198 → 327

DBB; Dof, BCAP, and BANK (DBB) motif,

cl02529
Location:344 → 393

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
NM_001310749.1 → NP_001297678.1 B-cell scaffold protein with ankyrin repeats isoform 2

See identical proteins and their annotated locations for NP_001297678.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC101978, EU051378

Consensus CDS

CCDS80026.1

UniProtKB/TrEMBL

A0A0G2JF26, B0F3S4

Related

ENSMUSP00000142366.2, ENSMUST00000196159.5

Conserved Domains (2) summary

pfam14545
Location:65 → 194

DBB; Dof, BCAP, and BANK (DBB) motif,

cl02529
Location:211 → 260

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

135759124..136031902 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501483.1 → XP_006501546.1 B-cell scaffold protein with ankyrin repeats isoform X1

UniProtKB/TrEMBL

Q0P699

Conserved Domains (2) summary

pfam14545
Location:198 → 326

DBB; Dof, BCAP, and BANK (DBB) motif,

pfam18567
Location:28 → 153

TIR_3; Toll/interleukin-1 receptor domain
XM_006501484.5 → XP_006501547.1 B-cell scaffold protein with ankyrin repeats isoform X2

UniProtKB/TrEMBL

A0A0G2JF26

Related

ENSMUSP00000142996.2, ENSMUST00000198206.2

Conserved Domains (1) summary

pfam14545
Location:65 → 193

DBB; Dof, BCAP, and BANK (DBB) motif,
XM_006501487.2 → XP_006501550.1 B-cell scaffold protein with ankyrin repeats isoform X3

Conserved Domains (2) summary

pfam14545
Location:198 → 326

DBB; Dof, BCAP, and BANK (DBB) motif,

pfam18567
Location:28 → 153

TIR_3; Toll/interleukin-1 receptor domain