Pglyrp3 peptidoglycan recognition protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pglyrp3provided by MGI
Official Full Name: peptidoglycan recognition protein 3provided by MGI
Primary source: MGI:MGI:2685266
See related: Ensembl:ENSMUSG00000042244 AllianceGenome:MGI:2685266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm420
Summary: Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Acts upstream of or within biological process involved in interaction with host; negative regulation of interferon-gamma production; and negative regulation of natural killer cell differentiation involved in immune response. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in several structures, including adrenal gland; alimentary system; liver; and nervous system. Orthologous to human PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (91919784..91939979)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92012477..92032672)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice.
Title: Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice.
Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice
Title: Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.
Pglyrp3 deficiency resulted in colitis-predisposing intestinal microflora and increased intestinal ATP
Title: Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Pglyrp3 (e-PCR), detects polymorphism
- UniSTS:546932

NoName (e-PCR)
- UniSTS:493221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within biological process involved in interaction with host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidoglycan recognition protein 3

Names: PGLYRPIalpha; PGRP-I-alpha; peptidoglycan recognition protein I-alpha; peptidoglycan recognition protein intermediate alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207247.4 → NP_997130.2 peptidoglycan recognition protein 3 precursor

See identical proteins and their annotated locations for NP_997130.2

Status: VALIDATED

Source sequence(s)

AC163215, BB619146

Consensus CDS

CCDS17545.1

UniProtKB/Swiss-Prot

A1A547, E9QMH8, Q6R1Z2

Related

ENSMUSP00000035737.5, ENSMUST00000047660.5

Conserved Domains (1) summary

smart00701
Location:185 → 325

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

91919784..91939979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501471.2 → XP_006501534.1 peptidoglycan recognition protein 3 isoform X1

Conserved Domains (1) summary

smart00701
Location:197 → 337

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme