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Igsf10 immunoglobulin superfamily, member 10 [ Mus musculus (house mouse) ]

Gene ID: 242050, updated on 5-Mar-2024

Summary

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Official Symbol
Igsf10provided by MGI
Official Full Name
immunoglobulin superfamily, member 10provided by MGI
Primary source
MGI:MGI:1923481
See related
Ensembl:ENSMUSG00000036334 AllianceGenome:MGI:1923481
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CMF608; Adlican2; 9030224D03; 6530405F15Rik
Summary
Involved in regulation of neuron migration. Predicted to be active in extracellular region. Is expressed in branchial arch; embryo mesenchyme; lip; and skeleton. Orthologous to human IGSF10 (immunoglobulin superfamily member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 6.6), subcutaneous fat pad adult (RPKM 3.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 D; 3 29.03 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59224156..59256836, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59316735..59344438, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CMF608-a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Segev O, et al. Bone, 2004 Feb. PMID 14962803
  2. IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. Howard SR, et al. EMBO Mol Med, 2016 Jun. PMID 27137492, Free PMC Article
  3. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
  4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tissue regeneration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162884.1 → NP_001156356.1  immunoglobulin superfamily member 10 precursor

    See identical proteins and their annotated locations for NP_001156356.1

    Status: PROVISIONAL

    Source sequence(s)
    AC122038, AC135238
    Consensus CDS
    CCDS50915.1
    UniProtKB/Swiss-Prot
    Q3UPM4, Q3V1M1
    Related
    ENSMUSP00000037246.7, ENSMUST00000039419.12
    Conserved Domains (11) summary
    smart00013
    Location:29 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 276
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2506 → 2593
    IG; Immunoglobulin
    smart00410
    Location:583 → 662
    IG_like; Immunoglobulin like
    COG4886
    Location:152 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1637 → 1708
    Ig; Immunoglobulin domain
    pfam13855
    Location:82 → 141
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2120 → 2199
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2403 → 2481
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:187 → 220
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    59224156..59256836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252616.2 → XP_030108476.1  immunoglobulin superfamily member 10 isoform X3

    Conserved Domains (6) summary
    smart00409
    Location:325 → 404
    IG; Immunoglobulin
    smart00410
    Location:1466 → 1550
    IG_like; Immunoglobulin like
    pfam07679
    Location:1862 → 1941
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1654 → 1733
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1669 → 1679
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1363 → 1453
    Ig; Immunoglobulin domain

  2. XM_006501468.5 → XP_006501531.1  immunoglobulin superfamily member 10 isoform X2

    Conserved Domains (10) summary
    smart00082
    Location:133 → 190
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:497 → 576
    IG; Immunoglobulin
    smart00410
    Location:2420 → 2507
    IG_like; Immunoglobulin like
    COG4886
    Location:66 → 316
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:21 → 44
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1551 → 1622
    Ig; Immunoglobulin domain
    pfam13855
    Location:1 → 55
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2034 → 2113
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2317 → 2395
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:101 → 134
    LRR_4; Leucine Rich repeats (2 copies)

  3. XM_006501467.5 → XP_006501530.1  immunoglobulin superfamily member 10 isoform X1

    See identical proteins and their annotated locations for XP_006501530.1

    UniProtKB/Swiss-Prot
    Q3UPM4, Q3V1M1
    Related
    ENSMUSP00000141391.2, ENSMUST00000194546.6
    Conserved Domains (11) summary
    smart00013
    Location:29 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 276
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2506 → 2593
    IG; Immunoglobulin
    smart00410
    Location:583 → 662
    IG_like; Immunoglobulin like
    COG4886
    Location:152 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1637 → 1708
    Ig; Immunoglobulin domain
    pfam13855
    Location:82 → 141
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2120 → 2199
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2403 → 2481
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:187 → 220
    LRR_4; Leucine Rich repeats (2 copies)

  4. XM_030252615.2 → XP_030108475.1  immunoglobulin superfamily member 10 isoform X2

    Conserved Domains (10) summary
    smart00082
    Location:133 → 190
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:497 → 576
    IG; Immunoglobulin
    smart00410
    Location:2420 → 2507
    IG_like; Immunoglobulin like
    COG4886
    Location:66 → 316
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:21 → 44
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1551 → 1622
    Ig; Immunoglobulin domain
    pfam13855
    Location:1 → 55
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2034 → 2113
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2317 → 2395
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:101 → 134
    LRR_4; Leucine Rich repeats (2 copies)

  5. XM_036163101.1 → XP_036018994.1  immunoglobulin superfamily member 10 isoform X3

    Conserved Domains (6) summary
    smart00409
    Location:325 → 404
    IG; Immunoglobulin
    smart00410
    Location:1466 → 1550
    IG_like; Immunoglobulin like
    pfam07679
    Location:1862 → 1941
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1654 → 1733
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1669 → 1679
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1363 → 1453
    Ig; Immunoglobulin domain

  6. XM_011240117.4 → XP_011238419.1  immunoglobulin superfamily member 10 isoform X1

    See identical proteins and their annotated locations for XP_011238419.1

    UniProtKB/Swiss-Prot
    Q3UPM4, Q3V1M1
    Conserved Domains (11) summary
    smart00013
    Location:29 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 276
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2506 → 2593
    IG; Immunoglobulin
    smart00410
    Location:583 → 662
    IG_like; Immunoglobulin like
    COG4886
    Location:152 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1637 → 1708
    Ig; Immunoglobulin domain
    pfam13855
    Location:82 → 141
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2120 → 2199
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2403 → 2481
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:187 → 220
    LRR_4; Leucine Rich repeats (2 copies)

  7. XM_036163100.1 → XP_036018993.1  immunoglobulin superfamily member 10 isoform X3

    Conserved Domains (6) summary
    smart00409
    Location:325 → 404
    IG; Immunoglobulin
    smart00410
    Location:1466 → 1550
    IG_like; Immunoglobulin like
    pfam07679
    Location:1862 → 1941
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1654 → 1733
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1669 → 1679
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1363 → 1453
    Ig; Immunoglobulin domain

  8. XM_006501465.5 → XP_006501528.1  immunoglobulin superfamily member 10 isoform X1

    See identical proteins and their annotated locations for XP_006501528.1

    UniProtKB/Swiss-Prot
    Q3UPM4, Q3V1M1
    Conserved Domains (11) summary
    smart00013
    Location:29 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 276
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2506 → 2593
    IG; Immunoglobulin
    smart00410
    Location:583 → 662
    IG_like; Immunoglobulin like
    COG4886
    Location:152 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1637 → 1708
    Ig; Immunoglobulin domain
    pfam13855
    Location:82 → 141
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2120 → 2199
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2403 → 2481
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:187 → 220
    LRR_4; Leucine Rich repeats (2 copies)

  9. XM_006501466.5 → XP_006501529.1  immunoglobulin superfamily member 10 isoform X1

    See identical proteins and their annotated locations for XP_006501529.1

    UniProtKB/Swiss-Prot
    Q3UPM4, Q3V1M1
    Related
    ENSMUSP00000141971.2, ENSMUST00000193455.6
    Conserved Domains (11) summary
    smart00013
    Location:29 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 276
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2506 → 2593
    IG; Immunoglobulin
    smart00410
    Location:583 → 662
    IG_like; Immunoglobulin like
    COG4886
    Location:152 → 402
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:1637 → 1708
    Ig; Immunoglobulin domain
    pfam13855
    Location:82 → 141
    LRR_8; Leucine rich repeat
    pfam07679
    Location:2120 → 2199
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2403 → 2481
    Ig_3; Immunoglobulin domain
    pfam12799
    Location:187 → 220
    LRR_4; Leucine Rich repeats (2 copies)

  10. XM_036163102.1 → XP_036018995.1  immunoglobulin superfamily member 10 isoform X3

    Conserved Domains (6) summary
    smart00409
    Location:325 → 404
    IG; Immunoglobulin
    smart00410
    Location:1466 → 1550
    IG_like; Immunoglobulin like
    pfam07679
    Location:1862 → 1941
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1654 → 1733
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1669 → 1679
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1363 → 1453
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V1M1.2 GenPept UniProtKB/Swiss-Prot:Q3V1M1

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