Akr1b1 aldo-keto reductase family 1 member B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1b1provided by RGD
Official Full Name: aldo-keto reductase family 1 member B1provided by RGD
Primary source: RGD:2092
See related: Ensembl:ENSRNOG00000009513 AllianceGenome:RGD:2092
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alr; Aldr1; ALDRED; Akr1b3; Akr1b4; ALR-P-I; RATALDRED
Summary: Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1001.4), Adrenal (RPKM 795.8) and 9 other tissues See more
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (63899222..63913315, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (62932033..62946126, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61706866..61720959, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomics-based screening of AKR1B1 as a therapeutic target and validation study for sepsis-associated acute kidney injury.
Title: Proteomics-based screening of AKR1B1 as a therapeutic target and validation study for sepsis-associated acute kidney injury.
Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity.
Title: Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity.
AKR1B1 played a vital role in astrocyte proliferation and energy metabolism induced by spinal cord injury.
Title: AKR1B1 Upregulation Contributes to Neuroinflammation and Astrocytes Proliferation by Regulating the Energy Metabolism in Rat Spinal Cord Injury.
Coincubation of cells with epalrestat prevented the signaling changes and renal cell injury induced by high glucose. Thus, aldose reductase inhibition represents a potential therapeutic strategy to prevent Diabetic nephropathy
Title: Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury.
The role of aldose reductase in the development of diabetic nephropathy: Aldose reductase was upregulated in diabetic rat renal tissues.
Title: Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats.
The presented results showed the ability of CMTI to affect the polyol pathway in diabetic rats in vivo.
Title: A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferes with the polyol pathway in streptozotocin-induced diabetic rats.
Activation of PI3K by 15-Deoxy-delta(12,14)-prostaglandin J2 increases the expression of aldose reductase through Nrf2.
Title: 15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells.
Data suggest that aldose reductase (AR) plays a mediatory role in ocular neovascularization as seen in diabetic retinopathy; inhibition of AR may have therapeutic potential in diabetic retinopathy.
Title: Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition.
analysis of the inhibition of aldose reductase by Gentiana lutea extracts
Title: Inhibition of aldose reductase by Gentiana lutea extracts.
Data suggest that inhibition of AR activity in lens prevents cataract development in diabetes (using chlorogenic acid as AR inhibitor in galactose-fed rat model). AR protein is highly expressed in lens epithelial cells/cortical fibers in this model.
Title: Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d4arb10 (e-PCR)
- UniSTS:121902

D4Mgh16 (e-PCR), detects polymorphism
- UniSTS:119378

D4Arb37 (e-PCR), detects polymorphism
- UniSTS:227697

RH94675 (e-PCR)
- UniSTS:119922

RH128270 (e-PCR)
- UniSTS:211578

PMC55360P2 (e-PCR)
- UniSTS:273335

GDB:4585363 (e-PCR)
- UniSTS:50616

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glucuronate reductase activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables allyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glyceraldehyde oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables glycerol dehydrogenase [NADP+] activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin H2 endoperoxidase reductase activity	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info
involved_in cellular response to methylglyoxal	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell maturation	ISO Inferred from Sequence Orthology more info
involved_in fructose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in inner medullary collecting duct development	IDA Inferred from Direct Assay more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in monosaccharide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of urine volume	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sorbitol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated protein kinase signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in Schwann cell microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mast cell granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane bounded cell projection cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aldo-keto reductase family 1 member B1

Names: AR; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); aldo-keto reductase family 1 member B; aldose reductase

NP_036630.1

EC 1.1.1.21

EC 1.1.1.300

EC 1.1.1.372

EC 1.1.1.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012498.1 → NP_036630.1 aldo-keto reductase family 1 member B1

See identical proteins and their annotated locations for NP_036630.1

Status: PROVISIONAL

Source sequence(s)

M60322

UniProtKB/Swiss-Prot

P07943

UniProtKB/TrEMBL

A0A8L2UIN9, A6IEL2

Related

ENSRNOP00000012879.3, ENSRNOT00000012879.4

Conserved Domains (2) summary

COG0656
Location:1 → 297

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:8 → 289

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]