Adrb2 adrenoceptor beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adrb2provided by RGD
Official Full Name: adrenoceptor beta 2provided by RGD
Primary source: RGD:2060
See related: AllianceGenome:RGD:2060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of ion transport; and response to steroid hormone. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in glutamatergic synapse. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (57912760..57914802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (55642459..55644501, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (57513792..57515834, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Catestatin in defense of oxidative-stress-induced apoptosis: A novel mechanism by activating the beta2 adrenergic receptor and PKB/Akt pathway in ischemic-reperfused myocardium.
Title: Catestatin in defense of oxidative-stress-induced apoptosis: A novel mechanism by activating the beta2 adrenergic receptor and PKB/Akt pathway in ischemic-reperfused myocardium.
In heart failure, local changes in PDE repertoire result in blunted beta2-AR signalling to cAMP in the vicinity of phospholemman.
Title: Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain.
Data show that beta 2 adrenergic receptors (beta2AR) Activation compartmentalizes beta-1 adrenergic receptor (beta1AR) signaling.
Title: β(2)-Adrenergic Stimulation Compartmentalizes β(1) Signaling Into Nanoscale Local Domains by Targeting the C-Terminus of β(1)-Adrenoceptors.
In cardiac myocytes, PDE4 insulates a mAKAPbeta-targeted PKA pool at the nuclear envelope that prevents nuclear PKA activation upon beta2-AR stimulation.
Title: PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes.
Adrb2 mRNA and protein are decreased in the hypercholesterolemic heart.
Title: MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium.
Docosahexaenoic acid upregulates beta2-AR in astrocytes, which undergo endocytosis and signals for sustained endosomal ERK activation to drive the differentiation process.
Title: Docosahexaenoic Acid (DHA) Induced Morphological Differentiation of Astrocytes Is Associated with Transcriptional Upregulation and Endocytosis of β(2)-AR.
Despite enhanced agonist-mediated downregulation of hepatic beta-ARs preferentially affecting the beta2-AR subtype, increased generation of both receptor subtypes during aging augments the pool of plasma membrane-bound beta-ARs coupled to adenylyl cyclase in hepatocytes.
Title: Altered expression of hepatic β-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver.
Estrogen replacement has an inhibitory effect on the psychological stress-induced pressor response through vasorelaxation via beta2-adrenoceptors, probably due to overexpression of beta2-adrenoceptor mRNA, in peripheral arteries of ovariectomized rats.
Title: Estrogen replacement attenuates stress-induced pressor responses through vasorelaxation via β(2)-adrenoceptors in peripheral arteries of ovariectomized rats.
CCL2 enhances the production of beta 2 adrenergic receptors.
Title: CCL2 Induces the Production of β2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline.
role of beta2- and beta3-adrenoceptors in arterial stiffness in a state of hypertension
Title: Role of β(2-) and β(3)-adrenoceptors in arterial stiffness in a state of hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:471069 (e-PCR)
- UniSTS:471069

Adrb2 (e-PCR), detects polymorphism
- UniSTS:471069

BI279712 (e-PCR)
- UniSTS:245027

D18Mgh11 (e-PCR)
- UniSTS:239652

D18Arb3 (e-PCR), detects polymorphism
- UniSTS:226902

D18Wox10 (e-PCR)
- UniSTS:239971

RH94735 (e-PCR)
- UniSTS:119982

ADRB2sts1 (e-PCR)
- UniSTS:258478

RH94736 (e-PCR)
- UniSTS:119983

ADRB2 (e-PCR)
- UniSTS:265908

Adrb2 (e-PCR), detects polymorphism
- UniSTS:256462

RH133790 (e-PCR)
- UniSTS:217073

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables B2 bradykinin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables beta2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables beta2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epinephrine binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables norepinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables norepinephrine binding	IEA Inferred from Electronic Annotation more info
enables norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor-receptor interaction	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in diaphragm contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in heat generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heat generation	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagosome maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of lipophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mini excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mini excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of the force of heart contraction by epinephrine	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine	ISO Inferred from Sequence Orthology more info
involved_in response to catecholamine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to monoamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	TAS Traceable Author Statement more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-2 adrenergic receptor

Names: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2, surface; beta-2 adrenoceptor; beta-2 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012492.2 → NP_036624.2 beta-2 adrenergic receptor

See identical proteins and their annotated locations for NP_036624.2

Status: VALIDATED

Source sequence(s)

BC086538

UniProtKB/Swiss-Prot

P10608, Q6LCR3

UniProtKB/TrEMBL

D7NIV9, Q8VBU7

Conserved Domains (2) summary

pfam00001
Location:50 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:48 → 340

7tm_4; Olfactory receptor