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Ralgapa2 Ral GTPase activating protein, alpha subunit 2 (catalytic) [ Mus musculus (house mouse) ]

Gene ID: 241694, updated on 21-Apr-2024

Summary

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Official Symbol
Ralgapa2provided by MGI
Official Full Name
Ral GTPase activating protein, alpha subunit 2 (catalytic)provided by MGI
Primary source
MGI:MGI:3036245
See related
Ensembl:ENSMUSG00000037110 AllianceGenome:MGI:3036245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P220; RGC2; AS250; pp250; A230067G21Rik
Summary
Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 4.9), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.33 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146079326..146354174, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (146239876..146512254, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 61 Neighboring gene STARR-seq mESC enhancer starr_05936 Neighboring gene predicted gene, 34629 Neighboring gene RIKEN cDNA A930019D19 gene Neighboring gene insulinoma-associated 1 Neighboring gene STARR-seq mESC enhancer starr_05939 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05941 Neighboring gene STARR-positive B cell enhancer ABC_E4508 Neighboring gene RIKEN cDNA 4933406D12 gene Neighboring gene STARR-seq mESC enhancer starr_05944 Neighboring gene STARR-seq mESC enhancer starr_05945 Neighboring gene predicted gene, 52577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Iida T, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 31622786, Free PMC Article
  2. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Saito R, et al. Oncogene, 2013 Feb 14. PMID 22450745
  3. Novel insulin-elicited phosphoproteins in adipocytes. Gridley S, et al. Cell Signal, 2005 Jan. PMID 15451025
  4. Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis. Uegaki M, et al. Carcinogenesis, 2019 Dec 31. PMID 31058283
  5. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Gridley S, et al. Cell Signal, 2006 Oct. PMID 16490346

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
    Title: Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
  2. loss of RalGAP function has a distinct role in promoting progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma.
    Title: Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
  3. study reports the identification and characterization of a Ral GAP complex (RG1, RGC2) that mediates the activation of RalA downstream of the PI 3-kinase/Akt pathway
    Title: A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1272

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Ral protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of exocyst localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ral GTPase-activating protein subunit alpha-2
Names
250 kDa substrate of Akt
ral GTPase-activating protein alpha subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033348.4 → NP_001028520.2  ral GTPase-activating protein subunit alpha-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845273, AL845430, AL935056
    Consensus CDS
    CCDS16831.2
    UniProtKB/Swiss-Prot
    A3KGS3, A3KGS5, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2
    UniProtKB/TrEMBL
    A0A0A0MQD7
    Related
    ENSMUSP00000105613.3, ENSMUST00000109986.9
    Conserved Domains (1) summary
    pfam02145
    Location:1702 → 1874
    Rap_GAP; Rap/ran-GAP

  2. NM_001408200.1 → NP_001395129.1  ral GTPase-activating protein subunit alpha-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845273, AL845430, AL935056
    Related
    ENSMUSP00000122039.2, ENSMUST00000131824.8

  3. NM_001408201.1 → NP_001395130.1  ral GTPase-activating protein subunit alpha-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845273, AL845430, AL935056
    UniProtKB/TrEMBL
    A0A2I3BPN8
    Related
    ENSMUSP00000153734.2, ENSMUST00000228797.2

  4. NM_001408202.1 → NP_001395131.1  ral GTPase-activating protein subunit alpha-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845273, AL845430
    Related
    ENSMUST00000109982.9

RNA

  1. NR_176472.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935056

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    146079326..146354174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161998.1 → XP_036017891.1  ral GTPase-activating protein subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    pfam02145
    Location:852 → 1024
    Rap_GAP; Rap/ran-GAP

RNA

  1. XR_374469.4 RNA Sequence

  2. XR_374468.4 RNA Sequence

  3. XR_003952992.2 RNA Sequence

  4. XR_004940347.1 RNA Sequence

  5. XR_004940346.1 RNA Sequence

  6. XR_866276.3 RNA Sequence

  7. XR_866277.4 RNA Sequence

  8. XR_866275.4 RNA Sequence

  9. XR_003952993.1 RNA Sequence

  10. XR_001782599.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KGS3.2 GenPept UniProtKB/Swiss-Prot:A3KGS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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