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Dzank1 double zinc ribbon and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

Gene ID: 241688, updated on 5-Mar-2024

Summary

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Official Symbol
Dzank1provided by MGI
Official Full Name
double zinc ribbon and ankyrin repeat domains 1provided by MGI
Primary source
MGI:MGI:2139080
See related
Ensembl:ENSMUSG00000037259 AllianceGenome:MGI:2139080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ankrd64; 2810039F03Rik; 6330439K17Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in eye photoreceptor cell development. Is expressed in eye; nervous system; and reproductive system. Orthologous to human DZANK1 (double zinc ribbon and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 22.9), frontal lobe adult (RPKM 19.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.02 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144312475..144369427, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144470555..144527507, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46768 Neighboring gene zinc finger protein 133, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05917 Neighboring gene STARR-seq mESC enhancer starr_05918 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F Neighboring gene retinoblastoma binding protein 9, serine hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. Shen AL, et al. PLoS One, 2016. PMID 27310661, Free PMC Article
  2. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650
  3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  4. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported.
    Title: Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107224, 6430408C01, 2810039F03Rik, 6330439K17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in eye photoreceptor cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
double zinc ribbon and ankyrin repeat-containing protein 1
Names
ankyrin repeat-containing protein C20orf12 homolog
likely ortholog of H. sapiens chromosome 20 open reading frame 12 (C20orf12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360361.1 → NP_001347290.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    B7ZNV9, E9Q4Z6
    Conserved Domains (5) summary
    cd00204
    Location:602 → 706
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:624 → 656
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:311 → 365
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated

  2. NM_001360362.1 → NP_001347291.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (3) is shorter, and has a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (4) summary
    PRK14559
    Location:359 → 458
    PRK14559; putative protein serine/threonine phosphatase; Provisional
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam12773
    Location:359 → 407
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated

  3. NM_001360363.1 → NP_001347292.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (4) is shorter, and has a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    AK163994, AL808119, BY254795, CJ256961
    Conserved Domains (3) summary
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam12773
    Location:311 → 365
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated

  4. NM_172859.3 → NP_766447.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_766447.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK032182, AK032632, AK163994, AL808119, BY254795, CJ256961
    Consensus CDS
    CCDS38254.1
    UniProtKB/Swiss-Prot
    A2AN93, Q8C008, Q8C060
    UniProtKB/TrEMBL
    E9Q4Z6
    Related
    ENSMUSP00000080643.6, ENSMUST00000081982.12
    Conserved Domains (6) summary
    cd00204
    Location:644 → 748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam03174
    Location:12 → 97
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:359 → 407
    DZR; Double zinc ribbon
    pfam12796
    Location:644 → 730
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:666 → 698
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144312475..144369427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239534.3 → XP_011237836.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (5) summary
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:638 → 670
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:311 → 365
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated
    cl39094
    Location:626 → 705
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006499512.4 → XP_006499575.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (6) summary
    PRK14559
    Location:358 → 457
    PRK14559; serine/threonine phosphatase
    sd00025
    Location:272 → 289
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:665 → 697
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:358 → 406
    DZR; Double zinc ribbon
    pfam12796
    Location:643 → 732
    Ank_2; Ankyrin repeats (3 copies)
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated

  3. XM_011239532.3 → XP_011237834.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (6) summary
    PRK14559
    Location:358 → 457
    PRK14559; serine/threonine phosphatase
    sd00025
    Location:272 → 289
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:679 → 711
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:358 → 406
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated
    cl39094
    Location:667 → 746
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006499511.4 → XP_006499574.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499574.1

    UniProtKB/TrEMBL
    B2RUH8, E9Q4Z6
    Conserved Domains (6) summary
    PRK14559
    Location:359 → 458
    PRK14559; serine/threonine phosphatase
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:680 → 712
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:359 → 407
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated
    cl39094
    Location:668 → 747
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030251166.2 → XP_030107026.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (6) summary
    sd00025
    Location:230 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:586 → 618
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:273 → 327
    DZR; Double zinc ribbon
    pfam12796
    Location:564 → 653
    Ank_2; Ankyrin repeats (3 copies)
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated
    pfam14803
    Location:245 → 278
    Nudix_N_2; Nudix N-terminal

  6. XM_036161991.1 → XP_036017884.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (6) summary
    PRK14559
    Location:321 → 420
    PRK14559; serine/threonine phosphatase
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:628 → 660
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:321 → 369
    DZR; Double zinc ribbon
    pfam12796
    Location:606 → 695
    Ank_2; Ankyrin repeats (3 copies)
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated

  7. XM_011239533.4 → XP_011237835.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    E9Q4Z6
    Conserved Domains (6) summary
    PRK14559
    Location:321 → 420
    PRK14559; serine/threonine phosphatase
    sd00025
    Location:229 → 249
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00045
    Location:642 → 674
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:321 → 369
    DZR; Double zinc ribbon
    pfam13287
    Location:32 → 100
    Fn3_assoc; Fn3 associated
    cl39094
    Location:630 → 709
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C008.2 GenPept UniProtKB/Swiss-Prot:Q8C008

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