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Lzts3 leucine zipper, putative tumor suppressor family member 3 [ Mus musculus (house mouse) ]

Gene ID: 241638, updated on 11-Apr-2024

Summary

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Official Symbol
Lzts3provided by MGI
Official Full Name
leucine zipper, putative tumor suppressor family member 3provided by MGI
Primary source
MGI:MGI:2656976
See related
Ensembl:ENSMUSG00000037703 AllianceGenome:MGI:2656976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prosapip1
Summary
Predicted to enable PDZ domain binding activity and protein self-association. Predicted to be involved in protein homooligomerization and regulation of dendritic spine morphogenesis. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine. Is expressed in several structures, including central nervous system; face; limb; metanephros; and sensory organ. Orthologous to human LZTS3 (leucine zipper tumor suppressor family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 53.5), cortex adult (RPKM 37.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 63.24 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130474685..130484764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130632765..130642866, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene arginine vasopressin Neighboring gene U box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Laguesse S, et al. Neuron, 2017 Sep 27. PMID 28890345, Free PMC Article
  2. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. Peng Y, et al. J Biol Chem, 2011 Nov 18. PMID 21949185, Free PMC Article
  3. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use.
    Title: Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine zipper putative tumor suppressor 3
Names
proSAP-interacting protein 1
proline rich synapse associated protein interacting protein 1 (Prosapip1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291027.1 → NP_001277956.1  leucine zipper putative tumor suppressor 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK148251, AK161711, BY258870, BY630564, BY636255, CO043440
    UniProtKB/Swiss-Prot
    A2AHG0
    Conserved Domains (1) summary
    pfam06818
    Location:448 → 643
    Fez1; Fez1

  2. NM_001291028.1 → NP_001277957.1  leucine zipper putative tumor suppressor 3 isoform c

    See identical proteins and their annotated locations for NP_001277957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK148251, AK161711, BY258870, BY630564, BY636255, CO043440, DN175861
    Consensus CDS
    CCDS71145.1
    UniProtKB/Swiss-Prot
    A2AHG0
    Conserved Domains (2) summary
    COG1196
    Location:231 → 426
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:351 → 550
    Fez1

  3. NM_197945.4 → NP_922936.3  leucine zipper putative tumor suppressor 3 isoform a

    See identical proteins and their annotated locations for NP_922936.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK148251, AK161711, BY258870, BY630564, BY636255, CO043440
    Consensus CDS
    CCDS50714.1
    UniProtKB/Swiss-Prot
    A2AHF9, A2AHG0, Q3TSY0, Q6PE51
    Related
    ENSMUSP00000037109.7, ENSMUST00000045761.7
    Conserved Domains (2) summary
    COG1196
    Location:346 → 539
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:465 → 664
    Fez1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130474685..130484764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251156.2 → XP_030107016.1  leucine zipper putative tumor suppressor 3 isoform X3

    Related
    ENSMUSP00000105889.2, ENSMUST00000110260.8
    Conserved Domains (2) summary
    COG1196
    Location:231 → 426
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:351 → 550
    Fez1

  2. XM_017318204.3 → XP_017173693.1  leucine zipper putative tumor suppressor 3 isoform X1

    UniProtKB/Swiss-Prot
    A2AHF9, A2AHG0, Q3TSY0, Q6PE51
    Related
    ENSMUSP00000086990.4, ENSMUST00000089561.10
    Conserved Domains (2) summary
    COG1196
    Location:346 → 539
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:465 → 664
    Fez1

  3. XM_030251155.2 → XP_030107015.1  leucine zipper putative tumor suppressor 3 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:328 → 521
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:447 → 646
    Fez1

  4. XM_036161971.1 → XP_036017864.1  leucine zipper putative tumor suppressor 3 isoform X4

    Conserved Domains (2) summary
    TIGR02169
    Location:234 → 398
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam06818
    Location:334 → 530
    Fez1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AHG0.1 GenPept UniProtKB/Swiss-Prot:A2AHG0

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