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Wdr76 WD repeat domain 76 [ Mus musculus (house mouse) ]

Gene ID: 241627, updated on 5-Mar-2024

Summary

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Official Symbol
Wdr76provided by MGI
Official Full Name
WD repeat domain 76provided by MGI
Primary source
MGI:MGI:1926186
See related
Ensembl:ENSMUSG00000027242 AllianceGenome:MGI:1926186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030457D09; 5830411K18Rik
Summary
Predicted to enable DNA binding activity and enzyme binding activity. Predicted to be involved in cellular response to DNA damage stimulus and regulation of DNA damage checkpoint. Predicted to be located in heterochromatin and site of DNA damage. Predicted to be active in nucleus. Orthologous to human WDR76 (WD repeat domain 76). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 5.6), CNS E11.5 (RPKM 5.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr76 in Genome Data Viewer
Location:
2 E5; 2 60.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121337204..121375341)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121506723..121544860)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WD repeat domain 76 pseudogene Neighboring gene mitochondrial ribosomal protein L51 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:121332344-121332527 Neighboring gene STARR-seq mESC enhancer starr_05528 Neighboring gene microfibrillar-associated protein 1A Neighboring gene STARR-seq mESC enhancer starr_05532 Neighboring gene FERM domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_05533 Neighboring gene STARR-seq mESC enhancer starr_05535 Neighboring gene STARR-seq mESC enhancer starr_05536 Neighboring gene septin 2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDR76 mediates obesity and hepatic steatosis via HRas destabilization. Park JC, et al. Sci Rep, 2019 Dec 23. PMID 31873167, Free PMC Article
  2. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Jeong WJ, et al. Nat Commun, 2019 Jan 17. PMID 30655611, Free PMC Article
  3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290986.1 → NP_001277915.1  WD repeat-containing protein 76 isoform a

    See identical proteins and their annotated locations for NP_001277915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK031592, BC094676, BY720216
    Consensus CDS
    CCDS38218.1
    UniProtKB/Swiss-Prot
    A6PWY4
    Related
    ENSMUSP00000106232.3, ENSMUST00000110602.9
    Conserved Domains (3) summary
    COG2319
    Location:214 → 484
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:218 → 258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:214 → 423
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001290987.1 → NP_001277916.1  WD repeat-containing protein 76 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK031592, BC094676, BY720216
    UniProtKB/Swiss-Prot
    A6PWY4
    Conserved Domains (3) summary
    COG2319
    Location:60 → 330
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:60 → 269
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001369185.1 → NP_001356114.1  WD repeat-containing protein 76 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This isoform encodes the longest isoform (c).
    Source sequence(s)
    AL928678
    Consensus CDS
    CCDS89546.1
    UniProtKB/Swiss-Prot
    A2ASQ8, A4FUV0, A6PWY4, Q504Z3, Q9CTV4
    Related
    ENSMUSP00000106234.2, ENSMUST00000110603.2
    Conserved Domains (2) summary
    sd00039
    Location:316 → 356
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:312 → 521
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_030234.2 → NP_084510.2  WD repeat-containing protein 76 isoform a

    See identical proteins and their annotated locations for NP_084510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK031592, AK162181, BC094676, BY019145
    Consensus CDS
    CCDS38218.1
    UniProtKB/Swiss-Prot
    A6PWY4
    Related
    ENSMUSP00000028676.6, ENSMUST00000028676.12
    Conserved Domains (3) summary
    COG2319
    Location:214 → 484
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:218 → 258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:214 → 423
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121337204..121375341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239529.3 → XP_011237831.1  WD repeat-containing protein 76 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6PWY4.1 GenPept UniProtKB/Swiss-Prot:A6PWY4

Gene LinkOut

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