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Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 [ Mus musculus (house mouse) ]

Gene ID: 241612, updated on 11-Apr-2024

Summary

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Official Symbol
Slc5a12provided by MGI
Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 12provided by MGI
Primary source
MGI:MGI:2138890
See related
Ensembl:ENSMUSG00000041644 AllianceGenome:MGI:2138890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMCT2; D630015G19
Summary
Enables lactate transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 48.3) See more
Orthologs
human all
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Genomic context

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Location:
2 E3; 2 56.75 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (110427644..110479690)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (110597299..110649345)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30319 Neighboring gene STARR-seq mESC enhancer starr_05369 Neighboring gene fin bud initiation factor homolog (zebrafish) Neighboring gene STARR-seq mESC enhancer starr_05370 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05371 Neighboring gene STARR-seq mESC enhancer starr_05372 Neighboring gene predicted gene, 52522 Neighboring gene anoctamin 3 Neighboring gene mucin 15 Neighboring gene STARR-seq mESC enhancer starr_05373 Neighboring gene POTE ankyrin domain family member 1 Neighboring gene RB1-inducible coiled-coil 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract. Teramae H, et al. Biomed Res, 2010 Aug. PMID 20834181
  2. Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring. Pucino V, et al. Cell Metab, 2019 Dec 3. PMID 31708446, Free PMC Article
  3. Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine. Ohkubo M, et al. Drug Metab Pharmacokinet, 2012. PMID 22123132
  4. Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Martin PM, et al. Invest Ophthalmol Vis Sci, 2007 Jul. PMID 17591909
  5. Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Srinivas SR, et al. Biochem J, 2005 Dec 15. PMID 16104846, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
    Title: Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
  2. A low affinity type of SMCT2-like transporter is in operation with high capacity throughout the small intestine, playing the role as the major intestinal nicotinate uptake transporter.
    Title: Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine.
  3. SMCT2 was localized in the brush border of enterocytes in the intestinal villi, and SMCT2 was localized in the brush border of is a jejunal type of SCMT.
    Title: The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract.
  4. low-affinity transporter SMCT2 initiates lactate absorption in the early parts of the proximal tubule followed by the participation of the high-affinity transporter SMCT1 in the latter parts of the proximal tubule.
    Title: Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.
  5. These data provide the first evidence for the expression of SMCT1 and SMCT2 in the retina and for the cell-type specific distribution of these transporters within the retina.
    Title: Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina.
  6. slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate
    Title: c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney.
  7. The cloning and characterization of slc5a12 (SMCT2) is reported.
    Title: Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lactate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-coupled monocarboxylate transporter 2
Names
electroneutral sodium monocarboxylate cotransporter
low-affinity sodium-lactate cotransporter
sodium solute cotransporter
solute carrier family 5 member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003915.2 → NP_001003915.1  sodium-coupled monocarboxylate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001003915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732495, BX005257
    Consensus CDS
    CCDS16512.1
    UniProtKB/Swiss-Prot
    Q49B93
    Related
    ENSMUSP00000047340.7, ENSMUST00000045972.13
    Conserved Domains (1) summary
    cl00456
    Location:3 → 531
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001177624.1 → NP_001171095.1  sodium-coupled monocarboxylate transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001171095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK165419, AL732495, BX005257
    Consensus CDS
    CCDS50656.1
    UniProtKB/Swiss-Prot
    Q0D2G1, Q49B93, Q6A4K8
    UniProtKB/TrEMBL
    B9EJ03
    Related
    ENSMUSP00000106655.3, ENSMUST00000111026.3
    Conserved Domains (1) summary
    cd11520
    Location:3 → 527
    SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    110427644..110479690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499489.4 → XP_006499552.1  sodium-coupled monocarboxylate transporter 2 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:1 → 339
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q49B93.1 GenPept UniProtKB/Swiss-Prot:Q49B93

Gene LinkOut

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