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Tspan18 tetraspanin 18 [ Mus musculus (house mouse) ]

Gene ID: 241556, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan18provided by MGI
Official Full Name
tetraspanin 18provided by MGI
Primary source
MGI:MGI:1917186
See related
Ensembl:ENSMUSG00000027217 AllianceGenome:MGI:1917186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720430O15; 2610042G18Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.7), adrenal adult (RPKM 19.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 51.37 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93032105..93164898, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93201760..93334551, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93032831-93033064 Neighboring gene predicted gene, 32683 Neighboring gene transformation related protein 53 inducible protein 11 Neighboring gene predicted gene, 32824 Neighboring gene predicted gene, 39882 Neighboring gene VISTA enhancer mm1603 Neighboring gene predicted gene, 39881 Neighboring gene predicted gene, 32745 Neighboring gene predicted gene 13807

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tspan18 is a novel regulator of thrombo-inflammation. Gavin RL, et al. Med Microbiol Immunol, 2020 Aug. PMID 32447449, Free PMC Article
  2. Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells. Noy PJ, et al. Haematologica, 2019 Sep. PMID 30573509, Free PMC Article
  3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
  4. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tspan18 is a novel regulator of thrombo-inflammation.
    Title: Tspan18 is a novel regulator of thrombo-inflammation.
  2. The findings identify Tspan18 as a novel regulator of endothelial cell Orai1/Ca2+ signaling and von Willebrand factor release in response to inflammatory stimuli.
    Title: Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium-ion regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium-mediated signaling using extracellular calcium source ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to cell periphery ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-18
Names
tspan-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183180.2 → NP_899003.1  tetraspanin-18

    See identical proteins and their annotated locations for NP_899003.1

    Status: VALIDATED

    Source sequence(s)
    AL691472, BB659903, BC052169
    Consensus CDS
    CCDS38182.1
    UniProtKB/Swiss-Prot
    Q80WR1
    Related
    ENSMUSP00000106896.3, ENSMUST00000111265.9
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93032105..93164898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499475.5 → XP_006499538.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499538.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  2. XM_006499476.5 → XP_006499539.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499539.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  3. XM_006499474.5 → XP_006499537.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499537.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  4. XM_011239525.3 → XP_011237827.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_011237827.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  5. XM_006499477.5 → XP_006499540.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499540.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Related
    ENSMUSP00000028646.3, ENSMUST00000028646.4
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WR1.1 GenPept UniProtKB/Swiss-Prot:Q80WR1

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