Lrrc55 leucine rich repeat containing 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc55provided by MGI
Official Full Name: leucine rich repeat containing 55provided by MGI
Primary source: MGI:MGI:2685197
See related: Ensembl:ENSMUSG00000075224 AllianceGenome:MGI:2685197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm351; A330097E02Rik
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC55 (leucine rich repeat containing 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 9.5), CNS E18 (RPKM 5.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.53 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (85018411..85029110, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (85188067..85198750, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
Title: Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation.
Title: Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation.
Lrrc55 is a novel prosurvival factor that is upregulated specifically in islets during pregnancy, and it prevents conversion of adaptive unfolded protein response to unresolved ER stress and apoptosis in beta-cells
Title: Lrrc55 is a novel prosurvival factor in pancreatic islets.
LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions
Title: +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

04.MMHAP38FLB1.seq (e-PCR)
- UniSTS:122778

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 55

Names: BK channel auxiliary gamma subunit LRRC55; BK channel auxilliary gamma subunit LRRC55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033346.5 → NP_001028518.2 leucine-rich repeat-containing protein 55 precursor

Status: VALIDATED

Source sequence(s)

AL928793

Consensus CDS

CCDS38167.2

UniProtKB/Swiss-Prot

Q3UY51

UniProtKB/TrEMBL

B9EIX5

Related

ENSMUSP00000157165.3, ENSMUST00000234267.3

Conserved Domains (4) summary

smart00013
Location:38 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:47 → 66

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:90 → 148

LRR_8; Leucine rich repeat

cl15307
Location:196 → 247

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

85018411..85029110 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499469.4 → XP_006499532.1 leucine-rich repeat-containing protein 55 isoform X1

See identical proteins and their annotated locations for XP_006499532.1

UniProtKB/TrEMBL

A0A3B2WBQ3, B9EIX5

Conserved Domains (4) summary

smart00013
Location:51 → 82

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:60 → 79

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 161

LRR_8; Leucine rich repeat

cl15307
Location:209 → 260

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006499468.5 → XP_006499531.1 leucine-rich repeat-containing protein 55 isoform X1

See identical proteins and their annotated locations for XP_006499531.1

UniProtKB/TrEMBL

A0A3B2WBQ3, B9EIX5

Related

ENSMUSP00000107228.2, ENSMUST00000111601.2

Conserved Domains (4) summary

smart00013
Location:51 → 82

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:60 → 79

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 161

LRR_8; Leucine rich repeat

cl15307
Location:209 → 260

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain