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Ypel4 yippee like 4 [ Mus musculus (house mouse) ]

Gene ID: 241525, updated on 21-Apr-2024

Summary

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Official Symbol
Ypel4provided by MGI
Official Full Name
yippee like 4provided by MGI
Primary source
MGI:MGI:3605071
See related
Ensembl:ENSMUSG00000034059 AllianceGenome:MGI:3605071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Is expressed in forebrain. Orthologous to human YPEL4 (yippee like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 48.4), liver E14 (RPKM 41.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84564355..84568999)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84734011..84738655)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 19 Neighboring gene zinc finger, DHHC domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_05007 Neighboring gene STARR-positive B cell enhancer ABC_E810 Neighboring gene CLP1, cleavage and polyadenylation factor I subunit Neighboring gene STARR-seq mESC enhancer starr_05008 Neighboring gene predicted gene, 19426 Neighboring gene microRNA 130a Neighboring gene STARR-seq mESC enhancer starr_05009 Neighboring gene serine (or cysteine) peptidase inhibitor, clade G, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Meyer K, et al. Cell, 2018 Sep 20. PMID 30197081
  2. Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. Mattebo A, et al. Sci Rep, 2021 Aug 5. PMID 34354145, Free PMC Article
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
  5. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
    Title: Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of erythrocyte clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein yippee-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005342.2 → NP_001005342.1  protein yippee-like 4

    See identical proteins and their annotated locations for NP_001005342.1

    Status: PROVISIONAL

    Source sequence(s)
    AB098743
    Consensus CDS
    CCDS16192.1
    UniProtKB/Swiss-Prot
    Q65Z93
    UniProtKB/TrEMBL
    A0A571BG63, Q0VEE5
    Related
    ENSMUSP00000088231.3, ENSMUST00000090729.9
    Conserved Domains (1) summary
    cl13152
    Location:28 → 118
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84564355..84568999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499466.4 → XP_006499529.1  protein yippee-like 4 isoform X1

    See identical proteins and their annotated locations for XP_006499529.1

    UniProtKB/Swiss-Prot
    Q65Z93
    UniProtKB/TrEMBL
    A0A571BG63, Q0VEE5
    Related
    ENSMUSP00000158708.2, ENSMUST00000238573.2
    Conserved Domains (1) summary
    cl13152
    Location:28 → 118
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. XM_036161892.1 → XP_036017785.1  protein yippee-like 4 isoform X1

    UniProtKB/Swiss-Prot
    Q65Z93
    UniProtKB/TrEMBL
    A0A571BG63, Q0VEE5
    Conserved Domains (1) summary
    cl13152
    Location:28 → 118
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q65Z93.1 GenPept UniProtKB/Swiss-Prot:Q65Z93

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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