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Zfp804a zinc finger protein 804A [ Mus musculus (house mouse) ]

Gene ID: 241514, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp804aprovided by MGI
Official Full Name
zinc finger protein 804Aprovided by MGI
Primary source
MGI:MGI:2442949
See related
Ensembl:ENSMUSG00000070866 AllianceGenome:MGI:2442949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf804a; C630007C17Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of dendritic spine maintenance; positive regulation of gene expression; and positive regulation of neuron projection development. Predicted to be located in several cellular components, including dendrite; growth cone; and neuronal cell body. Predicted to be active in nucleus. Is expressed in nervous system and tongue. Orthologous to human ZNF804A (zinc finger protein 804A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 2.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.06 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (81880473..82090223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (82050129..82259879)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04956 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene STARR-seq mESC enhancer starr_04957 Neighboring gene STARR-seq mESC enhancer starr_04958 Neighboring gene predicted gene, 23452 Neighboring gene STARR-seq mESC enhancer starr_04959 Neighboring gene STARR-seq mESC enhancer starr_04960 Neighboring gene STARR-seq mESC enhancer starr_04961 Neighboring gene STARR-seq mESC enhancer starr_04962 Neighboring gene STARR-seq mESC enhancer starr_04963 Neighboring gene STARR-seq mESC enhancer starr_04964 Neighboring gene STARR-seq mESC enhancer starr_04965 Neighboring gene STARR-seq mESC enhancer starr_04967 Neighboring gene STARR-seq mESC enhancer starr_04968 Neighboring gene STARR-seq mESC enhancer starr_04969 Neighboring gene predicted gene 13677 Neighboring gene STARR-seq mESC enhancer starr_04970 Neighboring gene STARR-seq mESC enhancer starr_04971 Neighboring gene RIKEN cDNA A130030D18 gene Neighboring gene mitochondrial ribosomal protein L18 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development. Dong F, et al. Mol Brain, 2021 Jan 14. PMID 33446247, Free PMC Article
  2. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. Huang Y, et al. Mol Psychiatry, 2021 Jun. PMID 33303946, Free PMC Article
  3. Histone H3.3 maintains genome integrity during mammalian development. Jang CW, et al. Genes Dev, 2015 Jul 1. PMID 26159997, Free PMC Article
  4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
    Title: ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
  2. Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.
    Title: Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 804A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175513.3 → NP_780722.2  zinc finger protein 804A

    See identical proteins and their annotated locations for NP_780722.2

    Status: VALIDATED

    Source sequence(s)
    AK035949, AK049881, BC035535
    Consensus CDS
    CCDS38160.1
    UniProtKB/Swiss-Prot
    A2AKY4, Q8BHY7
    Related
    ENSMUSP00000041941.8, ENSMUST00000047527.8
    Conserved Domains (1) summary
    pfam12171
    Location:57 → 84
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    81880473..82090223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239522.3 → XP_011237824.1  zinc finger protein 804A isoform X1

    Conserved Domains (1) summary
    pfam12171
    Location:57 → 84
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AKY4.1 GenPept UniProtKB/Swiss-Prot:A2AKY4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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