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TP53TG3 TP53 target 3 [ Homo sapiens (human) ]

Gene ID: 24150, updated on 10-Oct-2023

Summary

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Official Symbol
TP53TG3provided by HGNC
Official Full Name
TP53 target 3provided by HGNC
Primary source
HGNC:HGNC:30759
See related
Ensembl:ENSG00000183632 MIM:617482; AllianceGenome:HGNC:30759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P53TG3; TP53TG3A; TP53TG3E; TP53TG3F
Summary
Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 7.8), adrenal (RPKM 0.7) and 2 other tissues See more
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Genomic context

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Location:
16p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (32673530..32676165, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (33087984..33090621, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (32684851..32687486, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 153 member D, pseudogene Neighboring gene uncharacterized LOC107984013 Neighboring gene uncharacterized LOC105371177 Neighboring gene ABHD17A pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 16p11.2-p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2. Barber JC, et al. Eur J Hum Genet, 2013 Feb. PMID 22828807, Free PMC Article
  2. Identification of epistatic effects using a protein-protein interaction database. Sun YV, et al. Hum Mol Genet, 2010 Nov 15. PMID 20736252, Free PMC Article
  3. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. Ng CC, et al. Genes Chromosomes Cancer, 1999 Dec. PMID 10534768
  4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TP53-target gene 3 protein
Names
TP53-inducible gene 3 protein
p53 target gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016212.5 → NP_057296.1  TP53-target gene 3 protein

    See identical proteins and their annotated locations for NP_057296.1

    Status: VALIDATED

    Source sequence(s)
    AC138907
    Consensus CDS
    CCDS45475.1
    UniProtKB/Swiss-Prot
    B2R5K6, Q4KN31, Q9ULY9, Q9ULZ0
    Related
    ENSP00000381672.4, ENST00000398682.5

RNA

  1. NR_110886.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138907

  2. NR_110910.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138907

  3. NR_158180.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138907

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    32673530..32676165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545779.2 → XP_011544081.1  TP53-target gene 3 protein isoform X1

    See identical proteins and their annotated locations for XP_011544081.1

    UniProtKB/Swiss-Prot
    Q9ULZ0
    Related
    ENSP00000455448.1, ENST00000565622.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    33087984..33090621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379988.1 → XP_054235963.1  TP53-target gene 3 protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001267813.1: Suppressed sequence

    Description
    NM_001267813.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_015369.1: Suppressed sequence

    Description
    NM_015369.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULZ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULZ0

Gene LinkOut

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