U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp385b zinc finger protein 385B [ Mus musculus (house mouse) ]

Gene ID: 241494, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp385bprovided by MGI
Official Full Name
zinc finger protein 385Bprovided by MGI
Primary source
MGI:MGI:2444734
See related
Ensembl:ENSMUSG00000027016 AllianceGenome:MGI:2444734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp533; Znf385b; B830010L13Rik; C130013B13Rik
Summary
Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to act upstream of or within apoptotic process. Predicted to be active in nucleus. Is expressed in central nervous system; heart; limb bud; and retina. Orthologous to human ZNF385B (zinc finger protein 385B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 5.5), frontal lobe adult (RPKM 4.4) and 22 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 C3; 2 45.94 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (77240966..77648050, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (77410622..77817706, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04908 Neighboring gene predicted gene, 35317 Neighboring gene STARR-seq mESC enhancer starr_04909 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04910 Neighboring gene STARR-seq mESC enhancer starr_04911 Neighboring gene STARR-seq mESC enhancer starr_04912 Neighboring gene predicted gene 13944 Neighboring gene STARR-seq mESC enhancer starr_04913 Neighboring gene STARR-seq mESC enhancer starr_04914 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene predicted gene, 17927 Neighboring gene STARR-seq mESC enhancer starr_04915 Neighboring gene STARR-seq mESC enhancer starr_04916 Neighboring gene predicted gene, 35431 Neighboring gene STARR-seq mESC enhancer starr_04917 Neighboring gene CWC22 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E10118 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Spielmann M, et al. Genome Res, 2016 Feb. PMID 26755636, Free PMC Article
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 385B
Names
zinc finger protein 533

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113399.1 → NP_001106870.1  zinc finger protein 385B isoform 2

    See identical proteins and their annotated locations for NP_001106870.1

    Status: VALIDATED

    Source sequence(s)
    AI851853, AK050293, BC048543
    Consensus CDS
    CCDS50612.1
    UniProtKB/TrEMBL
    G5E8Y8
    Related
    ENSMUSP00000126801.2, ENSMUST00000171063.8
    Conserved Domains (2) summary
    sd00020
    Location:211 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:273 → 296
    zf-met; Zinc-finger of C2H2 type

  2. NM_001113400.1 → NP_001106871.1  zinc finger protein 385B isoform 3

    See identical proteins and their annotated locations for NP_001106871.1

    Status: VALIDATED

    Source sequence(s)
    AI851853, AK050293
    Consensus CDS
    CCDS50611.1
    UniProtKB/Swiss-Prot
    Q8BXJ8
    Related
    ENSMUSP00000107461.3, ENSMUST00000111830.9
    Conserved Domains (2) summary
    sd00020
    Location:185 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:247 → 270
    zf-met; Zinc-finger of C2H2 type

  3. NM_001363039.1 → NP_001349968.1  zinc finger protein 385B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845547, AL928537
    Conserved Domains (2) summary
    sd00020
    Location:206 → 268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:267 → 291
    zf-met; Zinc-finger of C2H2 type

  4. NM_178723.6 → NP_848838.2  zinc finger protein 385B isoform 1

    See identical proteins and their annotated locations for NP_848838.2

    Status: VALIDATED

    Source sequence(s)
    AI851853, AK046798, AK050293, AK149352, BC132352
    Consensus CDS
    CCDS16164.1
    UniProtKB/Swiss-Prot
    Q8BWQ7, Q8BXJ8
    UniProtKB/TrEMBL
    A2AS57
    Related
    ENSMUSP00000107462.2, ENSMUST00000111831.8
    Conserved Domains (2) summary
    sd00020
    Location:299 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:361 → 384
    zf-met; Zinc-finger of C2H2 type

RNA

  1. NR_156434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928537, BX520058

  2. NR_156435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928537

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    77240966..77648050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499456.3 → XP_006499519.1  zinc finger protein 385B isoform X3

    Conserved Domains (2) summary
    sd00020
    Location:312 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:374 → 397
    zf-met; Zinc-finger of C2H2 type

  2. XM_006499455.3 → XP_006499518.1  zinc finger protein 385B isoform X1

    Conserved Domains (2) summary
    sd00020
    Location:341 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:403 → 426
    zf-met; Zinc-finger of C2H2 type

  3. XM_030251112.1 → XP_030106972.1  zinc finger protein 385B isoform X11

    Conserved Domains (2) summary
    sd00020
    Location:345 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:407 → 430
    zf-met; Zinc-finger of C2H2 type

  4. XM_030251099.1 → XP_030106959.1  zinc finger protein 385B isoform X8

    Conserved Domains (2) summary
    sd00020
    Location:224 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:286 → 309
    zf-met; Zinc-finger of C2H2 type

  5. XM_006499458.4 → XP_006499521.1  zinc finger protein 385B isoform X5

    Conserved Domains (2) summary
    sd00020
    Location:253 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:315 → 338
    zf-met; Zinc-finger of C2H2 type

  6. XM_006499460.5 → XP_006499523.1  zinc finger protein 385B isoform X6

    Conserved Domains (2) summary
    sd00020
    Location:248 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:310 → 333
    zf-met; Zinc-finger of C2H2 type

  7. XM_036161862.1 → XP_036017755.1  zinc finger protein 385B isoform X2

    Conserved Domains (2) summary
    sd00020
    Location:306 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:367 → 391
    zf-met; Zinc-finger of C2H2 type

  8. XM_006499457.5 → XP_006499520.1  zinc finger protein 385B isoform X4

    Conserved Domains (2) summary
    sd00020
    Location:256 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:318 → 341
    zf-met; Zinc-finger of C2H2 type

  9. XM_030251103.1 → XP_030106963.1  zinc finger protein 385B isoform X9

    Conserved Domains (2) summary
    sd00020
    Location:198 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:260 → 283
    zf-met; Zinc-finger of C2H2 type

  10. XM_036161868.1 → XP_036017761.1  zinc finger protein 385B isoform X7

    Conserved Domains (2) summary
    sd00020
    Location:227 → 289
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:288 → 312
    zf-met; Zinc-finger of C2H2 type

  11. XM_006499462.5 → XP_006499525.1  zinc finger protein 385B isoform X7

    See identical proteins and their annotated locations for XP_006499525.1

    Conserved Domains (2) summary
    sd00020
    Location:227 → 289
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:288 → 312
    zf-met; Zinc-finger of C2H2 type

  12. XM_006499464.2 → XP_006499527.1  zinc finger protein 385B isoform X10

    Conserved Domains (2) summary
    sd00020
    Location:213 → 235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:35 → 58
    zf-met; Zinc-finger of C2H2 type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXJ8.1 GenPept UniProtKB/Swiss-Prot:Q8BXJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous