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Rbm45 RNA binding motif protein 45 [ Mus musculus (house mouse) ]

Gene ID: 241490, updated on 5-Mar-2024

Summary

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Official Symbol
Rbm45provided by MGI
Official Full Name
RNA binding motif protein 45provided by MGI
Primary source
MGI:MGI:2387367
See related
Ensembl:ENSMUSG00000042369 AllianceGenome:MGI:2387367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drb1; Drbp1; G430095G15Rik
Summary
Predicted to enable RNA binding activity and identical protein binding activity. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; sensory organ; and spinal cord. Orthologous to human RBM45 (RNA binding motif protein 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.8), CNS E14 (RPKM 13.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 44.94 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76200304..76214112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76369959..76383768)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene predicted gene, 52518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:75954028-75954329 Neighboring gene STARR-seq mESC enhancer starr_04889 Neighboring gene STARR-seq mESC enhancer starr_04890 Neighboring gene STARR-seq mESC enhancer starr_04891 Neighboring gene cytochrome c, testis Neighboring gene STARR-seq mESC enhancer starr_04893 Neighboring gene oxysterol binding protein-like 6 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of the Ets2 transcription factor in the proliferation, maturation, and survival of mouse thymocytes. Zaldumbide A, et al. J Immunol, 2002 Nov 1. PMID 12391198
  2. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. Tamada H, et al. Biochem Biophys Res Commun, 2002 Sep 13. PMID 12220514
  3. Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. Pyo JO, et al. J Biol Chem, 2008 Nov 7. PMID 18782777, Free PMC Article
  4. Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Jacobs FM, et al. Development, 2009 Jul. PMID 19515692, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
  2. ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH
    Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 45
Names
RB-1
developmentally regulated RNA binding protein 1
dopamine receptor binding 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153405.2 → NP_700454.1  RNA-binding protein 45

    See identical proteins and their annotated locations for NP_700454.1

    Status: VALIDATED

    Source sequence(s)
    AK080420, AK140861, BB832413, CB597326
    Consensus CDS
    CCDS16157.1
    UniProtKB/Swiss-Prot
    Q8BHN5, Q8C1Z5
    UniProtKB/TrEMBL
    Q3US38
    Related
    ENSMUSP00000040420.5, ENSMUST00000046389.5
    Conserved Domains (4) summary
    cd12366
    Location:23 → 104
    RRM1_RBM45; RNA recognition motif 1 in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:120 → 193
    RRM2_RBM45; RNA recognition motif 2 in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:248 → 320
    RRM3_RBM45; RNA recognition motif 3 in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:393 → 460
    RRM4_RBM45; RNA recognition motif 4 in RNA-binding protein 45 (RBM45) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76200304..76214112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952822.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178090.2: Suppressed sequence

    Description
    NM_178090.2: This RefSeq was permanently suppressed because it contains a single nucleotide frameshift mutation that truncates the C-terminus of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay (
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHN5.1 GenPept UniProtKB/Swiss-Prot:Q8BHN5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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