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Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 241391, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt5provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 5provided by MGI
Primary source
MGI:MGI:2179403
See related
Ensembl:ENSMUSG00000026828 AllianceGenome:MGI:2179403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4832424J23
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; retina; and skeleton. Orthologous to human GALNT5 (polypeptide N-acetylgalactosaminyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 32.93 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (57887832..57931039)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (57997850..58041027)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial pseudogene Neighboring gene predicted gene, 25388 Neighboring gene STARR-seq mESC enhancer starr_04536 Neighboring gene STARR-seq mESC enhancer starr_04537 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57771733-57772033 Neighboring gene STARR-seq mESC enhancer starr_04538 Neighboring gene STARR-seq mESC enhancer starr_04539 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57882224-57882524 Neighboring gene ermin, ERM-like protein Neighboring gene STARR-seq mESC enhancer starr_04540 Neighboring gene STARR-positive B cell enhancer ABC_E3374 Neighboring gene STARR-positive B cell enhancer ABC_E2036 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1589 Neighboring gene STARR-positive B cell enhancer ABC_E3375 Neighboring gene STARR-positive B cell enhancer ABC_E5917 Neighboring gene STARR-positive B cell enhancer ABC_E5918 Neighboring gene STARR-positive B cell enhancer ABC_E7817 Neighboring gene STARR-positive B cell enhancer ABC_E5919 Neighboring gene cytohesin 1 interacting protein Neighboring gene predicted gene 13546

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
  2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
  3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 5
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
galNAc-T5
polypeptide GalNAc transferase 5
pp-GaNTase 5
ppGaNTase-T5
protein-UDP acetylgalactosaminyltransferase 5
NP_766443.2
XP_006498111.1
XP_006498112.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172855.3 → NP_766443.2  polypeptide N-acetylgalactosaminyltransferase 5

    See identical proteins and their annotated locations for NP_766443.2

    Status: VALIDATED

    Source sequence(s)
    BC116331, BC116332
    Consensus CDS
    CCDS38125.1
    UniProtKB/Swiss-Prot
    A2AS75, Q8C102
    UniProtKB/TrEMBL
    Q14B51
    Related
    ENSMUSP00000108235.2, ENSMUST00000112616.8
    Conserved Domains (2) summary
    cd02510
    Location:489 → 790
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    smart00458
    Location:805 → 925
    RICIN; Ricin-type beta-trefoil

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    57887832..57931039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498049.3 → XP_006498112.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006498112.1

    UniProtKB/Swiss-Prot
    A2AS75, Q8C102
    UniProtKB/TrEMBL
    Q14B51
    Conserved Domains (2) summary
    cd02510
    Location:489 → 790
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    smart00458
    Location:805 → 925
    RICIN; Ricin-type beta-trefoil

  2. XM_006498048.5 → XP_006498111.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006498111.1

    UniProtKB/Swiss-Prot
    A2AS75, Q8C102
    UniProtKB/TrEMBL
    Q14B51
    Conserved Domains (2) summary
    cd02510
    Location:489 → 790
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    smart00458
    Location:805 → 925
    RICIN; Ricin-type beta-trefoil
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C102.2 GenPept UniProtKB/Swiss-Prot:Q8C102

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