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Zfp68 zinc finger protein 68 [ Mus musculus (house mouse) ]

Gene ID: 24135, updated on 27-Feb-2024

Summary

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Official Symbol
Zfp68provided by MGI
Official Full Name
zinc finger protein 68provided by MGI
Primary source
MGI:MGI:1344427
See related
Ensembl:ENSMUSG00000058291 AllianceGenome:MGI:1344427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB3; KRAZ2; Zfp70; mszf22; mszf49
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; female associated reproductive structure; inner cell mass; oocyte; and ovary. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 10.5), CNS E18 (RPKM 9.5) and 24 other tissues See more
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Genomic context

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See Zfp68 in Genome Data Viewer
Location:
5 G2; 5 77.1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138601914..138618005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138603652..138619743, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 24 Neighboring gene RIKEN cDNA 1700123K08 gene Neighboring gene STARR-seq mESC enhancer starr_14669 Neighboring gene RIKEN cDNA A430033K04 gene Neighboring gene STARR-positive B cell enhancer ABC_E1314 Neighboring gene STARR-seq mESC enhancer starr_14671 Neighboring gene STARR-seq mESC enhancer starr_14672 Neighboring gene STARR-seq mESC enhancer starr_14673 Neighboring gene FAM20C, golgi associated secretory pathway kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). Agata Y, et al. J Biol Chem, 1999 Jun 4. PMID 10347202
  2. An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. Percec I, et al. Genetics, 2003 Aug. PMID 12930754, Free PMC Article
  3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  4. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  5. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 68
Names
zinc finger protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044747.2 → NP_001038212.1  zinc finger protein 68 isoform b

    See identical proteins and their annotated locations for NP_001038212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' end which causes translation initiation from a downstream, in-frame start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK044831, AK082025, BY088951
    Consensus CDS
    CCDS39347.1
    UniProtKB/TrEMBL
    Q8BLK6
    Related
    ENSMUSP00000083013.5, ENSMUST00000085852.11
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:475 → 548
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:378 → 402
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001163797.1 → NP_001157269.1  zinc finger protein 68 isoform a

    See identical proteins and their annotated locations for NP_001157269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AK044831, AK082025, AK146092, BY088951
    Consensus CDS
    CCDS19801.1
    UniProtKB/TrEMBL
    Q9Z116
    Related
    ENSMUSP00000069615.5, ENSMUST00000063262.11
    Conserved Domains (6) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:234 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:541 → 563
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:10 → 49
    KRAB; KRAB box
    pfam13465
    Location:416 → 440
    zf-H2C2_2; Zinc-finger double domain

  3. NM_013844.2 → NP_038872.1  zinc finger protein 68 isoform a

    See identical proteins and their annotated locations for NP_038872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AB024005, AK082025, BY088951
    Consensus CDS
    CCDS19801.1
    UniProtKB/TrEMBL
    Q9Z116
    Related
    ENSMUSP00000106530.3, ENSMUST00000110905.9
    Conserved Domains (6) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:234 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:541 → 563
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:10 → 49
    KRAB; KRAB box
    pfam13465
    Location:416 → 440
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138601914..138618005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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