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Zfp53 zinc finger protein 53 [ Mus musculus (house mouse) ]

Gene ID: 24132, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp53provided by MGI
Official Full Name
zinc finger protein 53provided by MGI
Primary source
MGI:MGI:99200
See related
Ensembl:ENSMUSG00000057409 AllianceGenome:MGI:99200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAZ1; zfas8; Zfp-53; Zfp118; D030067O06Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.7), CNS E18 (RPKM 1.1) and 27 other tissues See more
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Genomic context

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Location:
17 A3.2; 17 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21709179..21742899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21488934..21533201)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51 Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290 Neighboring gene STARR-positive B cell enhancer ABC_E3186 Neighboring gene RIKEN cDNA 9330136K24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:21669090-21669243 Neighboring gene zinc finger protein 52 Neighboring gene STARR-positive B cell enhancer ABC_E9942 Neighboring gene zinc finger protein 948

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). Agata Y, et al. J Biol Chem, 1999 Jun 4. PMID 10347202
  2. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
  3. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 53
Names
Zinc finger protein 118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013843.3 → NP_038871.1  zinc finger protein 53

    See identical proteins and their annotated locations for NP_038871.1

    Status: VALIDATED

    Source sequence(s)
    AK030965, BY741862, CT010433
    Consensus CDS
    CCDS28440.1
    UniProtKB/TrEMBL
    Q9Z117
    Related
    ENSMUSP00000156751.2, ENSMUST00000233158.2
    Conserved Domains (3) summary
    COG5048
    Location:223 → 627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:508 → 528
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:53 → 93
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21709179..21742899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160610.1 → XP_036016503.1  zinc finger protein 53 isoform X1

    UniProtKB/TrEMBL
    Q9Z117
    Conserved Domains (3) summary
    COG5048
    Location:223 → 627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:508 → 528
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:53 → 93
    KRAB; KRAB box

  2. XM_030249806.2 → XP_030105666.1  zinc finger protein 53 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:182 → 586
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  3. XM_030249807.2 → XP_030105667.1  zinc finger protein 53 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:141 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:426 → 446
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036160611.1 → XP_036016504.1  zinc finger protein 53 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:103 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:388 → 408
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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