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Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 [ Mus musculus (house mouse) ]

Gene ID: 241308, updated on 11-Apr-2024

Summary

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Official Symbol
Ralgps1provided by MGI
Official Full Name
Ral GEF with PH domain and SH3 binding motif 1provided by MGI
Primary source
MGI:MGI:1922008
See related
Ensembl:ENSMUSG00000038831 AllianceGenome:MGI:1922008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RALGEF2; RALGPS1A; RalGEF 2; mKIAA0351; 5830418G11Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 21.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.25 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33023431..33261569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33133419..33371499, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1586 Neighboring gene solute carrier family 2, (facilitated glucose transporter), member 8 Neighboring gene GTPase activating RANGAP domain-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32888039-32888233 Neighboring gene STARR-seq mESC enhancer starr_04227 Neighboring gene STARR-seq mESC enhancer starr_04229 Neighboring gene STARR-positive B cell enhancer ABC_E2614 Neighboring gene STARR-positive B cell enhancer ABC_E2615 Neighboring gene predicted gene 13528 Neighboring gene predicted gene, 23546 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene predicted gene 13536 Neighboring gene zinc finger and BTB domain containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras. Omidvar N, et al. Mol Cell Biol, 2006 May. PMID 16648489, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ralgps1 is both necessary and sufficient for the inhibition of myeloid differentiation by Ras.
    Title: Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Ral protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-specific guanine nucleotide-releasing factor RalGPS1
Names
Ral guanine nucleotide exchange factor RalGPS1A
ral GEF with PH domain and SH3-binding motif 1
ral guanine nucleotide exchange factor 2
ralA exchange factor RalGPS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290570.1 → NP_001277499.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and also lacks two exons and uses an alternate splice site that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK129123, BC072656, CJ112478
    Consensus CDS
    CCDS71031.1
    UniProtKB/TrEMBL
    A0A0A0MQE4
    Related
    ENSMUSP00000048451.7, ENSMUST00000042615.13
    Conserved Domains (3) summary
    smart00147
    Location:38 → 271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:373 → 488
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:372 → 483
    PH; PH domain

  2. NM_001290572.1 → NP_001277501.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK017939, BC072656, CJ112478
    Consensus CDS
    CCDS79779.1
    UniProtKB/TrEMBL
    A0A0A0MQE4
    Related
    ENSMUSP00000118363.3, ENSMUST00000131298.7
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:391 → 506
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  3. NM_175211.5 → NP_780420.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform a

    See identical proteins and their annotated locations for NP_780420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK076767, BC072656, CJ112478
    Consensus CDS
    CCDS15939.1
    UniProtKB/Swiss-Prot
    A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
    UniProtKB/TrEMBL
    A0A0A0MQE4
    Related
    ENSMUSP00000088563.3, ENSMUST00000091039.5
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461 → 576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33023431..33261569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498037.4 → XP_006498100.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X7

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:390 → 505
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  2. XM_006498033.4 → XP_006498096.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:460 → 575
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  3. XM_030251025.2 → XP_030106885.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X9

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:21 → 252
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:354 → 469
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  4. XM_006498035.4 → XP_006498098.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:21 → 252
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:425 → 540
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  5. XM_006498034.5 → XP_006498097.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:38 → 271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:444 → 559
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  6. XM_030251023.2 → XP_030106883.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X8

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:38 → 271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:374 → 489
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  7. XM_036161819.1 → XP_036017712.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X11

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    cd13310
    Location:329 → 444
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46 → 227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  8. XM_036161817.1 → XP_036017710.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X10

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    cd13310
    Location:330 → 445
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46 → 227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  9. XM_036161812.1 → XP_036017705.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X5

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    cd13310
    Location:400 → 515
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46 → 227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  10. XM_030251028.1 → XP_030106888.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X13

    Conserved Domains (2) summary
    cd13310
    Location:250 → 365
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 147
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  11. XM_030251026.2 → XP_030106886.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X12

    Conserved Domains (2) summary
    cd13310
    Location:320 → 435
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 147
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  12. XM_030251022.2 → XP_030106882.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X6

    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:391 → 506
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  13. XM_006498032.4 → XP_006498095.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

    See identical proteins and their annotated locations for XP_006498095.1

    UniProtKB/Swiss-Prot
    A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461 → 576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  14. XM_030251011.1 → XP_030106871.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

    UniProtKB/Swiss-Prot
    A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
    UniProtKB/TrEMBL
    A0A0A0MQE4
    Conserved Domains (2) summary
    smart00147
    Location:46 → 288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461 → 576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RNA

  1. XR_004940327.1 RNA Sequence

  2. XR_003952801.2 RNA Sequence

  3. XR_374090.5 RNA Sequence

  4. XR_374091.4 RNA Sequence

  5. XR_374089.5 RNA Sequence

  6. XR_003952804.2 RNA Sequence

  7. XR_374092.5 RNA Sequence

  8. XR_003952802.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AR50.2 GenPept UniProtKB/Swiss-Prot:A2AR50

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