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Noxa1 NADPH oxidase activator 1 [ Mus musculus (house mouse) ]

Gene ID: 241275, updated on 5-Mar-2024

Summary

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Official Symbol
Noxa1provided by MGI
Official Full Name
NADPH oxidase activator 1provided by MGI
Primary source
MGI:MGI:2449980
See related
Ensembl:ENSMUSG00000036805 AllianceGenome:MGI:2449980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NY-CO-31; SDCCAG31
Summary
Enables superoxide-generating NADPH oxidase activator activity. Acts upstream of or within superoxide metabolic process. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytosol. Is expressed in pancreas and pancreas tip epithelium. Orthologous to human NOXA1 (NADPH oxidase activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 42.3), large intestine adult (RPKM 23.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Noxa1 in Genome Data Viewer
Location:
2 A3; 2 16.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24975679..24985217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25085667..25095205, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene microRNA 7664 Neighboring gene STARR-seq mESC enhancer starr_03956 Neighboring gene predicted gene, 39770 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene STARR-seq mESC enhancer starr_03957 Neighboring gene VISTA enhancer mm1454 Neighboring gene predicted gene 13387 Neighboring gene Notch-regulated ankyrin repeat protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel. Mironova E, et al. Am J Physiol Renal Physiol, 2022 Dec 1. PMID 36201326, Free PMC Article
  2. NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Vendrov AE, et al. Redox Biol, 2019 Feb. PMID 30576919, Free PMC Article
  3. Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Ambasta RK, et al. Free Radic Biol Med, 2006 Jul 15. PMID 16814099
  4. Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension. Vendrov AE, et al. Antioxid Redox Signal, 2022 Mar. PMID 34714114, Free PMC Article
  5. Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells. Janus P, et al. Cell Death Differ, 2020 Jul. PMID 31996779, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.
    Title: Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.
  2. NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel.
    Title: NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel.
  3. Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.
    Title: Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.
  4. Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells.
    Title: Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells.
  5. Our data support an important role for NOXA1-dependent NADPH oxidase activity in VSMC plasticity during restenosis and atherosclerosis, augmenting VSMC proliferation and migration and KLF4-mediated transition to macrophage-like cells, plaque inflammation, and expansion.
    Title: NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.
  6. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.
    Title: Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
  7. NoxA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMC) that regulates redox signaling and VSMC phenotype.
    Title: Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
  8. role in activating superoxide generation by the NADPH oxidase NOX1
    Title: Two novel proteins activate superoxide generation by the NADPH oxidase NOX1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide-generating NADPH oxidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within superoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADPH oxidase activator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163626.1 → NP_001157098.1  NADPH oxidase activator 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK087263, AL732585
    Consensus CDS
    CCDS50524.1
    UniProtKB/Swiss-Prot
    Q8CJ00
    Related
    ENSMUSP00000110014.2, ENSMUST00000114373.8
    Conserved Domains (5) summary
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    pfam07719
    Location:38 → 68
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:38 → 100
    TPR_11; TPR repeat
    cl02720
    Location:278 → 355
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl17036
    Location:365 → 417
    SH3; Src Homology 3 domain superfamily

  2. NM_172204.4 → NP_757341.3  NADPH oxidase activator 1 isoform 1

    See identical proteins and their annotated locations for NP_757341.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK087263, AL732585
    Consensus CDS
    CCDS15749.1
    UniProtKB/Swiss-Prot
    A2AJA1, Q80SY2, Q8BU68, Q8CJ00
    Related
    ENSMUSP00000037423.8, ENSMUST00000044018.8
    Conserved Domains (5) summary
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    pfam07719
    Location:38 → 68
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:38 → 100
    TPR_11; TPR repeat
    cl02720
    Location:286 → 363
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl17036
    Location:373 → 425
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24975679..24985217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJ00.1 GenPept UniProtKB/Swiss-Prot:Q8CJ00

Gene LinkOut

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