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Gpr158 G protein-coupled receptor 158 [ Mus musculus (house mouse) ]

Gene ID: 241263, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr158provided by MGI
Official Full Name
G protein-coupled receptor 158provided by MGI
Primary source
MGI:MGI:2441697
See related
Ensembl:ENSMUSG00000045967 AllianceGenome:MGI:2441697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mGlyR; mKIAA1136; 5330427M13Rik
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Located in membrane. Is expressed in eye; male reproductive gland or organ; nervous system; and small intestine. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.3), cortex adult (RPKM 13.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 14.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21372378..21835355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21367567..21830544)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 3 pseudogene Neighboring gene predicted gene, 54105 Neighboring gene STARR-seq mESC enhancer starr_03893 Neighboring gene STARR-seq mESC enhancer starr_03894 Neighboring gene STARR-seq mESC enhancer starr_03895 Neighboring gene STARR-seq mESC enhancer starr_03896 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03897 Neighboring gene STARR-seq mESC enhancer starr_03898 Neighboring gene STARR-seq mESC enhancer starr_03899 Neighboring gene predicted gene, 52587 Neighboring gene STARR-seq mESC enhancer starr_03901 Neighboring gene STARR-seq mESC enhancer starr_03902 Neighboring gene predicted gene, 24886 Neighboring gene predicted gene, 39766 Neighboring gene STARR-seq mESC enhancer starr_03903 Neighboring gene predicted gene, 39767 Neighboring gene STARR-seq mESC enhancer starr_03905 Neighboring gene STARR-seq mESC enhancer starr_03907 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. G protein-coupled receptor 158 modulates sensitivity to the sedative-hypnotic effect of ethanol in male mice. Wei S, et al. Alcohol Clin Exp Res (Hoboken), 2023 Jul. PMID 37128649
  2. Expression Mapping and Functional Analysis of Orphan G-Protein-Coupled Receptor GPR158 in the Adult Mouse Brain Using a GPR158 Transgenic Mouse. Chang J, et al. Biomolecules, 2023 Mar 5. PMID 36979415, Free PMC Article
  3. Gpr158 Deficiency Impacts Hippocampal CA1 Neuronal Excitability, Dendritic Architecture, and Affects Spatial Learning. Çetereisi D, et al. Front Cell Neurosci, 2019. PMID 31749686, Free PMC Article
  4. An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Condomitti G, et al. Neuron, 2018 Oct 10. PMID 30290982, Free PMC Article
  5. Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR. Laboute T, et al. Science, 2023 Mar 31. PMID 36996198, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression Mapping and Functional Analysis of Orphan G-Protein-Coupled Receptor GPR158 in the Adult Mouse Brain Using a GPR158 Transgenic Mouse.
    Title: Expression Mapping and Functional Analysis of Orphan G-Protein-Coupled Receptor GPR158 in the Adult Mouse Brain Using a GPR158 Transgenic Mouse.
  2. Deletion of GPR158 or RGS7 enhanced excitability of layer 2/3 PFC neurons and prevented the impact of stress.
    Title: The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.
  3. activation of the OCN/GPR158 pathway increases the expression of RbAp48 in the aged dentate gyrus and rescues age-related memory loss.
    Title: RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss.
  4. MiR-449a has a target dependent effect, inhibiting cell growth and migration by downregulation of CCND1 and suppressing neural phenotypes by inhibition of G protein coupled-receptor (GPR) 158.
    Title: Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.
  5. mediates osteocalcin regulation of cognition
    Title: Gpr158 mediates osteocalcin's regulation of cognition.
  6. expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression
    Title: Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.
  7. GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
    Title: Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.
  8. GPR158/179 recruited RGS complexes to the plasma membrane and augmented their ability to regulate GPCR signaling
    Title: GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled glycine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurotransmitter secretion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metabotropic glycine receptor
Names
probable G-protein coupled receptor 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004761.1 → NP_001004761.1  metabotropic glycine receptor precursor

    See identical proteins and their annotated locations for NP_001004761.1

    Status: VALIDATED

    Source sequence(s)
    AB093287, AK083234
    Consensus CDS
    CCDS15722.1
    UniProtKB/Swiss-Prot
    B1AWY4, Q8C419, Q8CHB0
    Related
    ENSMUSP00000049708.8, ENSMUST00000055946.8
    Conserved Domains (1) summary
    pfam00003
    Location:428 → 667
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    21372378..21835355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175706.3: Suppressed sequence

    Description
    NM_175706.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C419.2 GenPept UniProtKB/Swiss-Prot:Q8C419

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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